Effects of Interactions among Gene Polymorphisms of the Renin-Angiotensin-Aldosterone System on Hypertension in Turkish People from Southeast Anatolia

Basit Öğe Kaydı
dc.authoridGuler, Halil Ibrahim/0000-0002-7261-6790
dc.authoridKARAKAS CELIK, Sevim/0000-0003-0505-7850
dc.authoridBAYRAMOGLU, AYSEGUL/0000-0001-8567-807X
dc.contributor.authorArpaci, Abdullah
dc.contributor.authorUrhan-Kucuk, Meral
dc.contributor.authorBayramoglu, Aysegul
dc.contributor.authorGuler, Halil Ibrahim
dc.contributor.authorEcevit, Hasret
dc.contributor.authorSuner, Arif
dc.contributor.authorKarakas-Celik, Sevim
dc.date.accessioned2024-09-18T20:27:56Z
dc.date.available2024-09-18T20:27:56Z
dc.date.issued2019
dc.departmentHatay Mustafa Kemal Ãœniversitesien_US
dc.description.abstractIntroduction: Hypertension (HT) is characterized by high blood pressure. The reninangiotensin-aldosterone system (RAAS) plays a crucial role in blood pressure (BP) regulation by maintaining vascular tone and the water-sodium balance. We aimed to investigate whether there is any relation between AGT (M235T), ACE (I/D), and AGTR1 (A1166C) genetic polymorphisms and hypertension among Turkish people from Southeast Anatolia. Method and Results: A total of 210 individuals, consisting of 102 healthy controls and 108 patients with essential hypertension admitted to the Cardiology Department of the Adiyaman University Research and Application Hospital were included the study. DNA isolation was performed from the blood samples via commercial kit. Genotype determination was determined using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. Statistically significant differences were found between the control and patient groups in terms of genotype distribution and allelic frequencies of ACE I/D polymorphisms. Significant differences were found in the frequencies of ICM, DCM, DCT, DAT between the patient and control groups. Conclusions: In this study, we found a significant association of ACE I/D polymorphism with HT, and we showed that the I allele can increase the risk of HT in Turkish people from Southeast Anatolia. Although we did not find any association between independent AGT M235T and AGT1R A1166C polymorphisms and HT, we observed that the DCM, DCT, and DAT haplotypes of ACE/AGT1R/AGT polymorphisms reduced the risk of hypertension, while the ICM haplotype increased it.en_US
dc.description.sponsorshipResearch Foundation of Adiyaman University [TIPFBAP/2013-0004]en_US
dc.description.sponsorshipThis study was supported by a grant from the Research Foundation of Adiyaman University (TIPFBAP/2013-0004), Turkey.en_US
dc.identifier.doi10.2478/rrlm-2019-0011
dc.identifier.endpage168en_US
dc.identifier.issn1841-6624
dc.identifier.issn2284-5623
dc.identifier.issue2en_US
dc.identifier.startpage159en_US
dc.identifier.urihttps://doi.org/10.2478/rrlm-2019-0011
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10612
dc.identifier.volume27en_US
dc.identifier.wosWOS:000467103000005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherSciendoen_US
dc.relation.ispartofRevista Romana De Medicina De Laboratoren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjecthypertensionen_US
dc.subjectrenin-angiotensin-aldosterone system (RAAS)en_US
dc.subjectgenetic variationsen_US
dc.subjectACE I/Den_US
dc.subjecthaplotypeen_US
dc.titleEffects of Interactions among Gene Polymorphisms of the Renin-Angiotensin-Aldosterone System on Hypertension in Turkish People from Southeast Anatoliaen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
Ä°sim:
Tam Metin / Full Text
Boyut:
403.63 KB
Biçim:
Adobe Portable Document Format
Ä°ndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu