Genomic damage in patients with type-2 diabetes mellitus

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dc.authorscopusid24476534200
dc.authorscopusid7005021534
dc.authorscopusid58421692200
dc.authorscopusid55910302600
dc.authorscopusid58348410500
dc.contributor.authorBinici, D.N.
dc.contributor.authorKaraman, Ali
dc.contributor.authorCoşkun, M.
dc.contributor.authorUyanik O?lu, A.
dc.contributor.authorUçar, F.
dc.date.accessioned2024-09-19T15:47:01Z
dc.date.available2024-09-19T15:47:01Z
dc.date.issued2013
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractDNA damage seems to play a role in the pathogenesis of type-2 diabetes mellitus (DM2) and its complications. Several in vitro assays have been used to measure the DNA damage. In the present study, we aimed to investigate the frequency of sister chromatid exchange (SCE) and micronuclei (MN) in DM2 patients compared with healthy controls. SCE and MN tests were carried out with the blood-cell cultures from 50 DM2 patients and 30 healthy, age- and sex-matched control subjects. The mean age of the DM2 patients was 58.12 ± 13.39 years, with a mean duration of the diabetes of 5.40 ± 4.32 years. The mean level of HbA1c of the DM2 patients was 8.93 ± 2.56. Patients with DM2 showed a higher frequency of SCE compared with controls (7.11 ± 1.14 and 4.96 ± 0.92, p<0.001). Furthermore, the SCE frequency was positively correlated with the plasma HbA1c level (p<0.05), but there was no significant correlation between the duration of diabetes and SCE. On the other hand, our result showed a MN frequency significant increase in DM2 patients (3.45 ± 1.01 per 1000 cells) relative to that of the control group (1.79 ± 0.67 per 1000 cells) (p<0.001), but there was no significant correlation between the duration of diabetes, HbA1c and MN. In conclusion, these results suggest that DM2 is a condition with genomic instability characterized by an increased level of SCE and MN. Hyperglycemia-induced oxidative stress may be the underlying factor of the increased SCE and MN frequency.en_US
dc.identifier.endpage156en_US
dc.identifier.issn1015-8146
dc.identifier.issue2en_US
dc.identifier.pmid24032284en_US
dc.identifier.scopus2-s2.0-84884321331en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage149en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/14922
dc.identifier.volume24en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofGenetic Counselingen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiabetes mellitusen_US
dc.subjectMicronucleusen_US
dc.subjectPathogenesisen_US
dc.subjectSister chromatid exchangeen_US
dc.titleGenomic damage in patients with type-2 diabetes mellitusen_US
dc.typeArticleen_US

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