Comparison of Immunological and Virological Recovery with Rapid, Early, and Late Start of Antiretroviral Treatment in Naive Plwh Real-World Data

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dc.authoridCandevir, Aslihan/0000-0001-9340-516X
dc.authoridALKAN, Sevil/0000-0003-1944-2477
dc.contributor.authorYildirim, Figen Sarigul
dc.contributor.authorCandevir, Aslihan
dc.contributor.authorAkhan, Sila
dc.contributor.authorKaya, Selcuk
dc.contributor.authorCabalak, Mehmet
dc.contributor.authorErsoz, Gulden
dc.contributor.authorInan, Dilara
dc.date.accessioned2024-09-18T20:26:43Z
dc.date.available2024-09-18T20:26:43Z
dc.date.issued2023
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground: Rapid initiation of antiretroviral therapy (ART) reduces the transmission of HIV infection in the community. This study aimed to determine whether rapid ART initiation is effective compared to standard ART treatment in our country. Methods: Patients were grouped based on time to treatment initiation. HIV RNA levels, CD+4 T cell count, CD4/CD8 ratio, and ART regimens were recorded at baseline and follow-up visits for 12 months. Results: There were 368-ART naive adults (treatment initiated at the time of HIV diagnosis; 143 on the first day, 48 on the secondseventh day, and 177 after the seventh day). Although virological suppression rates at 12th months were higher in all groups, over 90% on average, there were no statistically significant differences in HIV-1 RNA suppression rates, CD+4 T cell count, and CD4/CD8 ratio normalization in the studied months but in multivariate logistic regression analysis; showed a significant correlation between both virological and immunological response and those with CD4+ T <350 cells/mL at 12th month in total patients. Conclusion: Our findings support the broader application of recommendations for rapid ART initiation in HIV patients.en_US
dc.identifier.doi10.2147/IJGM.S393370
dc.identifier.endpage1877en_US
dc.identifier.issn1178-7074
dc.identifier.pmid37213471en_US
dc.identifier.scopus2-s2.0-85160296181en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1867en_US
dc.identifier.urihttps://doi.org/10.2147/IJGM.S393370
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10496
dc.identifier.volume16en_US
dc.identifier.wosWOS:000994365300001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherDove Medical Press Ltden_US
dc.relation.ispartofInternational Journal of General Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHIVen_US
dc.subjectARTen_US
dc.subjectantiretroviralen_US
dc.subjectrapid starten_US
dc.titleComparison of Immunological and Virological Recovery with Rapid, Early, and Late Start of Antiretroviral Treatment in Naive Plwh Real-World Dataen_US
dc.typeArticleen_US

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