Comparison of clomiphene citrate and low dose recombinant fsh for induction of ovulation in infertilewomen with polycystic ovary syndrome

Basit Öğe Kaydı
dc.authorscopusid56586172400
dc.authorscopusid36128379000
dc.authorscopusid36898801800
dc.authorscopusid56115704100
dc.authorscopusid56585724500
dc.contributor.authorAkçelIk, Yeliz
dc.contributor.authorÇögendez, Ebru
dc.contributor.authorSIlfeler, Dilek Benk
dc.contributor.authorEken, Meryem
dc.contributor.authorKarakaya, Selda
dc.date.accessioned2024-09-19T15:45:34Z
dc.date.available2024-09-19T15:45:34Z
dc.date.issued2015
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective: In our study, we aim to compare the treatment success and complication rates of clomiphene citrate (CC) and gonadotopins (r-FSH) using low dose step-up protocol, which are both frequently used as induction of ovulation protocols in patients with polycystic ovary syndrome (PCOS). Material and Methods: 138 patients with PCOS who presented at our infertility outpatient clinic and underwent ovulation induction were included in the study. Diagnosis of PCOS was reached using Rotterdam Criteria after exclusion of other etiological factors. Induction of ovulation was performed on 86 patients with CC and 52 patients with recombinant FSH (r-FSH) using low dose step-up protocol. Clomiphene citrate (n=86) was administered between the 5th and 9th days of the menstrual cycle with an initial dose of 50 mg/day. Ovulation induction with r-FSH (n=52) was done using low dose step-up protocol with an initial dose of 75 IU/day. Results: Number of follicles was significantly higher in patients in the r-FSH group (p=0.01). The incidence of ovarian hyperstimulation syndrome (OHSS) did not differ significantly among the groups (p=0.487). Also there was no significant difference in pregnancy ratios between two groups (p=0.064). Pregnancy ratios in the r-FSH and CC groups were found to be 12.5% and 5.9%, respectively. Of the pregnant subjects in the CC groups (n=8), one had a miscarriage at 10th gestational week; one live birth and 1 stillbirth was observed while pregnancies of the remaining 5 (62.5%) were maintained. Within the r-FSH group, where 16 subjects got pregnant, 6 live births (37.5%) and 1 stillbirth (6.3%) observed, and 2 subjects (12.5%) had first trimester abortus. 7 subjects of this group (43.8%) had their pregnancies maintained, while two of these were multiple pregnancies (one couplet and one triplet). Conclusion: Clomiphene citrate should be the first line treatment in the ovulation induction of patients with PCOS due to its low costs, easier patient monitorization (oral use), and lower risk of multiple pregnancies and OHSS. On the other hand, we think that administration of r-FSH in PCOS patients using low dose step-up protocol is a safe approach. Therefore, it should be the treatment of choice in patients who do not respond to CC of maximum dosage or for 6 or more cycles. Copyright ©2015 by Türkiye Klinikleri.en_US
dc.identifier.doi10.5336/gynobstet.2014-41444
dc.identifier.endpage26en_US
dc.identifier.issn1300-0306
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-84926615845en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage19en_US
dc.identifier.urihttps://doi.org/10.5336/gynobstet.2014-41444
dc.identifier.urihttps://hdl.handle.net/20.500.12483/14775
dc.identifier.volume25en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherOrtadogŸu Reklam Tanitim Yayincilik Turizm Egitim Insaat Sanayi ve Ticaret A.S.en_US
dc.relation.ispartofTurkiye Klinikleri Jinekoloji Obstetriken_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectClomipheneen_US
dc.subjectGonadotropinsen_US
dc.subjectInfertilityen_US
dc.subjectPolycystic ovary syndromeen_US
dc.titleComparison of clomiphene citrate and low dose recombinant fsh for induction of ovulation in infertilewomen with polycystic ovary syndromeen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu