Does somatostatin decrease hemorrhage from injured liver in rats?

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dc.authorscopusid56251336100
dc.authorscopusid22936975500
dc.authorscopusid26642369200
dc.authorscopusid6603344865
dc.contributor.authorAkçora, Bülent
dc.contributor.authorAltug, Enes M.
dc.contributor.authorFansa, Iyad
dc.contributor.authorNisanoglu, Vedat
dc.date.accessioned2024-09-19T15:43:49Z
dc.date.available2024-09-19T15:43:49Z
dc.date.issued2009
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractIn portal hypertensive patients, somatostatin (SMT) and octreotide have been widely used to decrease variceal bleeding because of its splanchnic hypoperfusion effect. The aim of this study was to explore the effects of somatostatin treatment for decreasing blood loss of uncontrolled liver hemorrhage model in rats.Twenty-one male rats were divided into 3 groups including group 1; nontreatment, group 2; isotonic saline infusion and group 3; isotonic saline plus SMT infusion. Intra-abdominal bleeding was induced by transection of median lobe of liver. Mean arterial pressures (MAP), amount of intra-peritoneal blood collection and hematocrit (Hct) changes were evaluated for 60 minutes.There was no difference in the MAP changes between the groups until 25th minute. Thereafter, MAP remained similar in the group 1 while gradually increased (P < 0.05) in the group 2 and 3. There was no statistically significant difference between the groups 2 and 3. End of study, the highest Hct value was determined in the nontreatment group (41.0 ± 3.26 %) and it significantly different from other two groups. We found increase of Htc value in the group 3 (32.3 ± 2.75 %) when compared with group 2 (29.7 ± 4.19 %), but it was not statistically significant. The highest intra-peritoneal blood volume was determined in group 2. We found decrease of the hemorrhage in the group 3 when compared with the group 2, but it was not statistically significant. Somatostatin using has a tendency, although not statistically significant, to decrease of intraperitoneal hemorrhage from liver in the rat model. © 2009 OMU All rights reserved.en_US
dc.identifier.doi10.5835/jecm.omu.26.01.004
dc.identifier.endpage46en_US
dc.identifier.issn1300-2996
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-81755188011en_US
dc.identifier.scopusquality#BAŞV!en_US
dc.identifier.startpage42en_US
dc.identifier.urihttps://doi.org/10.5835/jecm.omu.26.01.004
dc.identifier.urihttps://hdl.handle.net/20.500.12483/14575
dc.identifier.volume26en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofJournal of Experimental and Clinical Medicine (Turkey)en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBleedingen_US
dc.subjectLiver hemorrhageen_US
dc.subjectPortal hypertensionen_US
dc.subjectRat modelen_US
dc.subjectSomatostatinen_US
dc.subjectTraumaen_US
dc.titleDoes somatostatin decrease hemorrhage from injured liver in rats?en_US
dc.typeArticleen_US

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