Effects of ischemia/reperfusion on ß cells of pancreas and protective effects of melatonin treatment

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dc.authorscopusid14822825900
dc.authorscopusid12766697800
dc.authorscopusid35072897800
dc.authorscopusid26424989000
dc.authorscopusid57207594810
dc.contributor.authorYildirim, Ayse
dc.contributor.authorTuncer, Mehmet Cudi
dc.contributor.authorPamukçu, Özlem
dc.contributor.authorAktas, Ayfer
dc.contributor.authorAkkus, Murat
dc.date.accessioned2024-09-19T15:45:28Z
dc.date.available2024-09-19T15:45:28Z
dc.date.issued2009
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractOxygen free radicals are considered to be important components involved in the pathophysiological tissue alterations observed during ischemia-reperfusion (I/R). In this study, we investigated the putative protective effects of melatonin treatment on pancreatic I/R injury. Sprague Dawley male rats were subjected to 30 min of pancreatic pedicle occlusion followed by 90 min reperfusion. Melatonin (10 mg/kg. s.c) was administrated 30 min prior to ischemia or I/R application. At the end of the reperfusion periods, rats were decapitated. Pancreatic samples were taken for transmission electron microscopy. The results indicated that ischemia created b cell damage as evidenced by dilatation between the nucleus inner and outer membrane and degeneration on islets of Langerhans cells, was reversed by melatonin treatment. As melatonin administration reversed these microscopic damage, it seems likely that melatonin protects pancreatic tissue against oxidative damage.en_US
dc.identifier.doi10.4067/S0717-95022009000200036
dc.identifier.endpage525en_US
dc.identifier.issn0717-9367
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-70349602446en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage519en_US
dc.identifier.urihttps://doi.org/10.4067/S0717-95022009000200036
dc.identifier.urihttps://hdl.handle.net/20.500.12483/14704
dc.identifier.volume27en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherUniversidad de la Fronteraen_US
dc.relation.ispartofInternational Journal of Morphologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCellsen_US
dc.subjectIschemiaen_US
dc.subjectMelatoninen_US
dc.subjectPancreasen_US
dc.subjectReperfusionen_US
dc.titleEffects of ischemia/reperfusion on ß cells of pancreas and protective effects of melatonin treatmenten_US
dc.title.alternativeEfectos de la isquemia/reperfusión sobre células ß del páncreas y efectos protectores del tratamiento de melatoninaen_US
dc.typeArticleen_US

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