Role of Inflammatory Mediators in the Prediction Angiographic Thrombus in Patients with Acute Coronary Syndrome

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dc.contributor.authorTasin, Veyis
dc.contributor.authorKuvandik, Guven
dc.contributor.authorKarakus, Ali
dc.contributor.authorSahan, Mustafa
dc.contributor.authorDuru, Mehmet
dc.contributor.authorKurt, Mustafa
dc.contributor.authorOzer, Cahit
dc.date.accessioned2024-09-18T19:50:19Z
dc.date.available2024-09-18T19:50:19Z
dc.date.issued2015
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractAim: Inflammatory mechanisms had played a major role in the formation and prognosis of acute myocardial infarction. Inflammatory mediators was assciated with negative consequences of acute myocardial infarction. This study tested the hypothesis that in the acute phase of acute coronary syndrome, leukocyte count, neutrophil count, neutrophil lymphocyte ratio, and high sensitivity C reactive protein (hsCRP) are predictive of angiographic thrombus formation in the infarct related artery. Material and Method: This prospective study included 150 consecutive patients with acute coronary syndrome. Patients were assigned to a thrombus formation group (n=65) and a non thrombus formation group (n=85). Blood samples for measurement of hsCRP and for routine blood laboratory studies were collected before to coronary angiography. Numerical data were expressed as mean +/- Standard deviation. Nominal data were expressed as the number and percentage. Comparisons between groups, chi-square test was used for nominal variables. Comparisons between groups, t-test was used for numerical data. All statistical analyzes, p < 0.05 was considered significant. Results: The levels of hsCRP, total leukocyte counts, neutrophil counts, and neutrophil/lymphocyte ratios were substantially higher in the thrombus formation group than in the non thrombus formation group patients (for each, P < 0.05). T-test analyses identified hsCRP, leukocyte count, neutrophil count, and neutrophil/lymphocyte ratio as independent predictors of thrombus formation in the infarct-related artery (for each, P < 0.05). Discussion: In patients with acute coronary syndrome, higher leukocyte conut, neutrophil count, neutrophil / lymphocyte ratio and level of hsCRP are predictors to indicate thrombus formation.en_US
dc.identifier.doi10.4328/JCAM.2522
dc.identifier.endpage12en_US
dc.identifier.issn1309-0720
dc.identifier.issn1309-2014
dc.identifier.startpage9en_US
dc.identifier.urihttps://doi.org/10.4328/JCAM.2522
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7359
dc.identifier.volume6en_US
dc.identifier.wosWOS:000215585400016en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isotren_US
dc.publisherDerman Medical Publen_US
dc.relation.ispartofJournal of Clinical and Analytical Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcute Coronery Syndromeen_US
dc.subjectThrombus Formationen_US
dc.subjectInflammatory Mediatorsen_US
dc.titleRole of Inflammatory Mediators in the Prediction Angiographic Thrombus in Patients with Acute Coronary Syndromeen_US
dc.typeArticleen_US

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