The effect of continuous positive airway pressure treatment on inflammatory parameters and periostin levels in patients with obstructive sleep apnea syndrome

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dc.authoriddikmen, nursel/0000-0002-5923-400X
dc.authoridBabayigit, Cenk/0000-0001-9760-6081
dc.contributor.authorTosun, Fatma
dc.contributor.authorBabayigit, Cenk
dc.contributor.authorDikmen, Nursel
dc.contributor.authorDogan, Serdar
dc.contributor.authorDirican, Emre
dc.date.accessioned2024-09-18T20:52:50Z
dc.date.available2024-09-18T20:52:50Z
dc.date.issued2023
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground The purpose of the study was to examine the effects of continuous positive airway pressure (CPAP) treatment on inflammation parameters in patients with obstructive sleep apnea syndrome (OSAS). Methods Patients aged 18 to 65 years who underwent polysomnography (PSG) in the sleep clinic between January 1, 2019, and December 31, 2019, were included in the study. Patients with severe OSAS initiated treatment with CPAP. Patients and control subjects were assessed for levels of periostin, TNF-alpha, TGF-beta, and IL-6. Patients were re-evaluated 3 months later. Comparisons for the serum markers were made between controls and patients of different severity of OSAS. Comparisons of serum markers were also made between baseline and 3 month follow-up. Results A total of 92 patients were enrolled in the study, including 25 controls (apnea-hypopnea index or AHI < 5/h), 39 patents with mild to moderate OSAS who did not receive CPAP, and 28 patients with severe OSAS receiving CPAP treatment. When all three groups were compared, levels of periostin, TNF-alpha, TGF-beta, and IL-6, as inflammatory markers, were higher in the OSAS group, though not at a statistically significant level. In patients with severe OSAS, there were statistically significant decreases in the TGF-beta 1, TNF-alpha, and IL-6 values between baseline values and the same measures taken after 3 months of CPAP treatment. Periostin values also decreased after treatment, but this decrease was not at a significant level. Conclusion Inflammatory parameters of patients with OSAS were significantly higher compared with healthy participants. Regression of inflammation was detected after CPAP treatment.en_US
dc.description.sponsorshipHatay Mustafa Kemal University [19.U.013]en_US
dc.description.sponsorshipOur study was supported by the Hatay Mustafa Kemal University Scientific Research Projects Coordinator (Project Number: 19.U.013).en_US
dc.identifier.doi10.1007/s11325-022-02616-z
dc.identifier.endpage282en_US
dc.identifier.issn1520-9512
dc.identifier.issn1522-1709
dc.identifier.issue1en_US
dc.identifier.pmid35478293en_US
dc.identifier.scopus2-s2.0-85128893750en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage275en_US
dc.identifier.urihttps://doi.org/10.1007/s11325-022-02616-z
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11431
dc.identifier.volume27en_US
dc.identifier.wosWOS:000794874200001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofSleep and Breathingen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectObstructive sleep apnea syndromeen_US
dc.subjectPeriostinen_US
dc.subjectInflammationen_US
dc.subjectContinuous positive airway pressure (CPAP)en_US
dc.titleThe effect of continuous positive airway pressure treatment on inflammatory parameters and periostin levels in patients with obstructive sleep apnea syndromeen_US
dc.typeArticleen_US

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