Molecular epidemiology and risk factors in extended-spectrum beta lactamase positive and quinolone-resistant Escherichia coli strains isolated from urinary tract infections

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dc.authorscopusid57194484938
dc.authorscopusid36477499400
dc.authorscopusid14038550900
dc.authorscopusid7004087924
dc.authorscopusid35612683100
dc.authorscopusid54388675100
dc.authorscopusid36604669500
dc.contributor.authorKilinc, Cetin
dc.contributor.authorInci, Melek
dc.contributor.authorYula, Erkan
dc.contributor.authorOzer, Burcin
dc.contributor.authorDuran, Nizami
dc.contributor.authorDurmaz, Suleyman
dc.contributor.authorKaya, Yusuf Selim
dc.date.accessioned2024-09-19T15:45:34Z
dc.date.available2024-09-19T15:45:34Z
dc.date.issued2015
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractIntroduction: The study was designed to investigate the epidemiology, risk factors, and clonal relationships in extended-spectrum beta lactamase (ESBL)-positive and quinolone resistant Escherichia coli strains isolated from urinary tract infections. Materials and methods: The study included 96 E. coli strains isolated from urine samples and identified as the infection agent. All the strains were ESBL positive and quinolone resistant. ESBL production was evaluated by the double disc synergy test. The clonal proximity of the isolates was determined with Rep-PCR method. Results: Fifty-two (54.2%) of the 96 isolates were isolated from nosocomial infections, and 44 (45.8%) were isolated from community- acquired infections. Three common risk factors for ESBL-positive E.coli infections were identified. The most common risk factor was hospitalization in the last 6 months. The Rep-PCR technique detected 29 clones, of which nine were major clones and 20 were sporadic. Conclusion: The identification of clonal relationships using Rep-PCR can reveal the source of infections and means of dissemination. Community-acquired isolates that cause infections may be associated with hospitalization. Strains colonized in hospital for along time can increase infections in various departments. An increase in the resistance to any drug in any unit of a hospital may be the harbinger of a pandemic. The source of infection and ways of spread can be identified most accurately by the demonstration of clonal relationships.en_US
dc.identifier.endpage1039en_US
dc.identifier.issn0393-6384
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-84945190822en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1035en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/14776
dc.identifier.volume31en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherA. CARBONE Editoreen_US
dc.relation.ispartofActa Medica Mediterraneaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectClonal proximityen_US
dc.subjectEscherichia colien_US
dc.subjectExtended-spectrum beta lactamaseen_US
dc.subjectQuinolone resistanceen_US
dc.subjectRepetitive-sequence-based polymerase chain reactionen_US
dc.titleMolecular epidemiology and risk factors in extended-spectrum beta lactamase positive and quinolone-resistant Escherichia coli strains isolated from urinary tract infectionsen_US
dc.typeArticleen_US

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