Comparison of sugammadex and conventional reversal on postoperative nausea and vomiting: a randomized, blinded trial

Basit Öğe Kaydı
dc.contributor.authorKoyuncu, Onur
dc.contributor.authorTurhanoglu, Selim
dc.contributor.authorAkkurt, Cagla Ozbakis
dc.contributor.authorKarcioglu, Murat
dc.contributor.authorOzkan, Mustafa
dc.contributor.authorOzer, Cahit
dc.contributor.authorSessler, Daniel I.
dc.date.accessioned2024-09-18T20:59:10Z
dc.date.available2024-09-18T20:59:10Z
dc.date.issued2015
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractStudy Objective: To determine whether the new selective binding agent sugammadex causes less postoperative nausea and vomiting (PONY) than the cholinesterase inhibitor neostigmine. Design: Prospective, randomized, double-blinded study. Setting: University-affiliated hospital. Patients: One hundred American Society of Anesthesiologists physical status 1 and 2 patients scheduled for extremity surgery. Interventions: Patients were randomly assigned to neostigmine (70 mu g/kg) and atropine (0.4 mg per mg neostigmine) or sugammadex 2 mg/kg for neuromuscular antagonism at the end of anesthesia, when 4 twitches in response to train-of-four stimulation were visible with fade. Measurements: We recorded PONY, recovery parameters, antiemetic consumption, and side effects. Main Results: Nausea and vomiting scores were lower in the sugammadex patients upon arrival in the postanesthesia care unit (med: 0 [min-max, 0-3] vs med: 0 [min-max, 0-3]; P <.05), but thereafter low and comparable. Postoperative antiemetic and analgesic consumption were similar in each group. Extubation (median [interquartile range], 3 [1-3.25] vs 4 [1-3.25]; P <.001) first eye opening (4 [3-7.25] vs 7 [5-11]; P <.001), and head lift (4 [2-7.25] vs 8 [11-25]; P <.001) in minutes were shorter in patients given sugammadex. Postoperative heart rates were significantly lower in all measured times patients given neostigmine. Conclusions: Nondepolarizing neuromuscular blocking antagonism with sugammadex speeds recovery of neuromuscular strength but only slightly and transiently reduces PONY compared with neostigmine and atropine. (C) 2014 Elsevier Inc. All rights reserved.en_US
dc.description.sponsorshipMercken_US
dc.description.sponsorshipThe authors have no financial relationship with any organization. Supported by internal funds only. The Department of Outcomes Research is supported by grants from Merck, and Dr Sessler has served on a Merck advisory board.en_US
dc.identifier.doi10.1016/j.jclinane.2014.08.010
dc.identifier.endpage56en_US
dc.identifier.issn0952-8180
dc.identifier.issn1873-4529
dc.identifier.issue1en_US
dc.identifier.pmid25544263en_US
dc.identifier.scopus2-s2.0-84923250748en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage51en_US
dc.identifier.urihttps://doi.org/10.1016/j.jclinane.2014.08.010
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12430
dc.identifier.volume27en_US
dc.identifier.wosWOS:000350531100009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofJournal of Clinical Anesthesiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSugammadexen_US
dc.subjectNeostigmineen_US
dc.subjectPostoperative nauseaen_US
dc.subjectVomitingen_US
dc.titleComparison of sugammadex and conventional reversal on postoperative nausea and vomiting: a randomized, blinded trialen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ N/A ]
İsim:
Tam Metin / Full Text
Boyut:
254.89 KB
Biçim:
Adobe Portable Document Format
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu