Doxycycline/collagen/chondroitin sulfate delivery systems used for cartilage regeneration

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dc.authorscopusid7202222017
dc.authorscopusid57204214637
dc.authorscopusid55892071600
dc.authorscopusid57163228600
dc.authorscopusid6507509366
dc.authorscopusid7006538915
dc.authorscopusid42060908100
dc.contributor.authorMarin, Maria-Minodora
dc.contributor.authorAlbu Kaya, M?d?lina Georgiana
dc.contributor.authorGhica, Mihaela Violeta
dc.contributor.authorD?nil?, Elena
dc.contributor.authorCoar?, Gheorghe
dc.contributor.authorPopa, L?cr?mioara
dc.contributor.authorChelaru, Ciprian
dc.date.accessioned2024-09-19T15:41:16Z
dc.date.available2024-09-19T15:41:16Z
dc.date.issued2020
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description8th International Conference on Advanced Materials and Systems, ICAMS 2020 -- 1 October 2020 through 3 October 2020 -- Virtual, Online -- 261649en_US
dc.description.abstractCartilage damage is difficult to self-heal due to an avascular microenvironment and distinct mechanical properties. These features are a challenge in designing a cartilaginous tissue with repairing effect without producing any local infections. Thus, a biodegradable scaffold in which the drug can be incorporated is preferable. Drug delivery systems based on collagen sponges have progressively become remarkable biomaterials for different medical applications. The aim of this work was to design and characterize some collagen/chondroitin sulfate supports with doxycycline for cartilage tissue regeneration. The doxycycline should prevent the development of potential infections. Collagen, chondroitin sulfate and doxycycline gels were cross-linked with different concentrations of glutaraldehyde and then freeze-dried in order to obtain collagen matrices. The structural characteristics for the new synthesized biomaterials were firstly assessed by infrared spectroscopy (FT-IR), and scaffolds morphology was then evaluated by optical microscopy and water uptake. The enzymatic biodegradation was also performed. Also, the sponges surface properties were quantified through contact angle. The in vitro doxycycline kinetics release was performed with a dissolution equipment and the release mechanism was investigated. The obtained results recommend these new scaffolds based on doxycycline/collagen/chondroitin sulfate as a promising approach for the treatment of cartilage problems. © 2020 Toate drepturile asupra acestei edi?ii sunt rezervate editorilor.en_US
dc.description.sponsorshipRace and Difference Initiative, Emory University, RDI, (6PFE/16.10.2018, PN 19 17 03 02); Ministerul Cercet?rii şi Inov?rii, MCIen_US
dc.identifier.doi10.24264/icams-2020.II.16
dc.identifier.endpage206en_US
dc.identifier.issn2068-0783
dc.identifier.scopus2-s2.0-85112173395en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage201en_US
dc.identifier.urihttps://doi.org/10.24264/icams-2020.II.16
dc.identifier.urihttps://hdl.handle.net/20.500.12483/14142
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherInst. Nat. Cercetare-Dezvoltare Text. Pielarieen_US
dc.relation.ispartofICAMS Proceedings of the International Conference on Advanced Materials and Systemsen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChondroitin sulfateen_US
dc.subjectCollagenen_US
dc.subjectDoxycyclineen_US
dc.titleDoxycycline/collagen/chondroitin sulfate delivery systems used for cartilage regenerationen_US
dc.typeConference Objecten_US

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