Evaluation of the age related changes in dog brains

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dc.contributor.authorHaziroglu, R.
dc.contributor.authorGuvenc, T.
dc.contributor.authorTunca, R.
dc.contributor.authorOzsoy, S. Y.
dc.contributor.authorOzyildiz, Z.
dc.date.accessioned2024-09-18T19:52:30Z
dc.date.available2024-09-18T19:52:30Z
dc.date.issued2010
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractIn this study it was aimed to compare the pathological findings on the brains of aged and young dogs. The research material consisted the brains of 20 dogs over 10 years old and brains of 10 dogs with an age of 1-2 years old. The brains were first of all examined macroscopically afterwards the tissue samples were taken from telencephalon, mesencephalon, rhombencephalon for histopathological and immunohistochemical investigations. In the aged dogs brains macroscopic examinations revealed meningeal thickness and ventricular dilatation. Microscopically, fibrosis at choroid plexus, meninges and vascular walls also ependymal defects, gliosis and neuronal depletion were observed in the aged dogs brains. On semi quantitative examination of the sections, a statistically significant increase on Glial Fibrillary Acidic Protein (GFAP) and 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase (CNPase) expressions were determined in old dogs compared to young dogs (P<0.01).en_US
dc.identifier.endpage78en_US
dc.identifier.issn0035-1555
dc.identifier.issn2258-0646
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-77951234811en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage72en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7469
dc.identifier.volume161en_US
dc.identifier.wosWOS:000276433300005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherEcole Nationale Veterinaire Toulouseen_US
dc.relation.ispartofRevue De Medecine Veterinaireen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAgingen_US
dc.subjectbrainen_US
dc.subjectdogen_US
dc.subjectimmunoperoxidaseen_US
dc.titleEvaluation of the age related changes in dog brainsen_US
dc.typeArticleen_US

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