The protective role of polyphenols on blood cells in rats exposed to lead

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dc.contributor.authorAksu, Devrim Saripinar
dc.contributor.authorDidin, Mustafa
dc.contributor.authorKayikci, Fatma
dc.date.accessioned2024-09-18T20:29:31Z
dc.date.available2024-09-18T20:29:31Z
dc.date.issued2012
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe present study investigated the protective potential of the polyphenols in pomegranate juice against the detrimental effects of lead exposure on the hematological system and antioxidant parameters of rat red blood cells. Forty adult male Sprague Dawley rats weighing about 300 g were allocated randomly to four groups: a control group that received normal food and water; a positive control group that received a daily dose of 2000 ppm lead (as lead acetate) in their drinking water for 5 weeks; a low treatment group that received a daily dose of 2000 ppm lead together with 30 mu l pomegranate juice (PJ; equivalent to 1050 mu mol total polyphenols) by gavages for 5 weeks; and a high treatment group that received 2000 ppm lead and 60 mu l PJ (equivalent to 2100 mu mol total polyphenols) daily for 5 weeks. The plasma lead level was significantly (p<0.001) decreased as the plasma copper and zinc levels were significantly increased (p<0.001) in rats received PJ. Significant increases (p<0.001) in red blood cell (RBC) and white blood cell (WBC) counts, and haemoglobin (Hb) and packet cell volume (PCV) were found in both PJ groups compared to the rats exposed to lead alone. Rats that received PJ in addition to lead showed erythrocyte glutathione and plasma ceruloplasmin levels and erythrocyte superoxide dismutase and catalase activities' that were almost close to the control values. These observations indicated that treatment of rats with polyphenols might have produced amelioration in hematological system of rats exposed to lead, protecting the level of copper, zinc and antioxidants by against lead induced damage in blood cells.en_US
dc.description.sponsorshipMKUBAP [08 G 0101]en_US
dc.description.sponsorshipThis project was supported by MKUBAP (08 G 0101).en_US
dc.identifier.endpage57en_US
dc.identifier.issn1841-6624
dc.identifier.issn2284-5623
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-84872554957en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage47en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10903
dc.identifier.volume20en_US
dc.identifier.wosWOS:000309439200006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSciendoen_US
dc.relation.ispartofRevista Romana De Medicina De Laboratoren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLeaden_US
dc.subjectpolyphenolsen_US
dc.subjectpomegranate juiceen_US
dc.subjectoxidative stressen_US
dc.subjectblood cellen_US
dc.subjectraten_US
dc.titleThe protective role of polyphenols on blood cells in rats exposed to leaden_US
dc.typeArticleen_US

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