The protective effects of lycopene on the loss of body weight and histopathological lesions in liver, kidney, heart, and brain tissue of rats exposed to subchronically differential doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin

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dc.authorscopusid14037995800
dc.authorscopusid6507605026
dc.authorscopusid6507928515
dc.authorscopusid54684472800
dc.contributor.authorSakin, Fatih
dc.contributor.authorÇeribaşi, Ali Osman
dc.contributor.authorServi, Kadir
dc.contributor.authorL?cr?mioara, Popa
dc.date.accessioned2024-09-19T15:47:03Z
dc.date.available2024-09-19T15:47:03Z
dc.date.issued2011
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate the possible protective role of lycopene (LYC) on body weight changes, and histopathological lesions on liver, kidney, heart, and brain tissue in male rats exposed to subchronically differential doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a highly toxic xenobiotic. Forty-eight rats were divided into six groups. The first group received 0.5 mL corn oil as control; the second group was treated with10 mg/kg bw/day LYC. Groups 3 and 4 were treated with 50 and 500 ng/kg bw/day of TCDD, respectively. Groups 5 and 6 were subjected to 50 and 500 ng/kg bw/day of TCDD along with 10 mg/kg bw/day of LYC, simultaneously. The period of the experiment was 13 weeks. In TCDD-treated groups, a dose-related depression of mean body weight was observed when compared to control. Simultaneously LYC administration reduced the loss of body weight and partially or totally recovered the formed histopathological lesions in liver, kidney, and heart tissue of rats exposed to TCDD. As a result, it is suggested that LYC has a protective effect against the loss of body weight and toxicity caused by TCDD.en_US
dc.identifier.endpage870en_US
dc.identifier.issn0014-8237
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-83455225284en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage860en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/14939
dc.identifier.volume59en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofFarmaciaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDioxinen_US
dc.subjectHistopathologyen_US
dc.subjectLycopeneen_US
dc.subjectToxicityen_US
dc.titleThe protective effects of lycopene on the loss of body weight and histopathological lesions in liver, kidney, heart, and brain tissue of rats exposed to subchronically differential doses of 2,3,7,8-tetrachlorodibenzo-p-dioxinen_US
dc.typeArticleen_US

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