Serum Matrix Metalloproteinase-9, Tissue Inhibitor of Metalloproteinase-1 and Matrix Metalloproteinase-9/Neutrophil Gelatinase-associated Lipocalin Complex Levels in Patients with Early-stage Diabetic Nephropathy

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dc.authoridTURGUT, FARUK/0000-0003-1910-7433
dc.contributor.authorCakirca, Gokhan
dc.contributor.authorTurgut, Faruk Hilmi
dc.date.accessioned2024-09-18T20:15:10Z
dc.date.available2024-09-18T20:15:10Z
dc.date.issued2018
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractIntroduction. This study was aimed to investigate the efficacy of matrix metalloproteinase-9 (MMP-9), tissue inhibitor of metalloproteinase-1 (TIMP-1), and the neutrophil gelatin-aseassocia ted lipocalin (NGAL)-bound form of MMP-9 (MMP-9/NGAL complex) markers in the determination of early nephropathy in patients with type 2 diabetes mellitus. Materials and Methods. Twenty-five type 2 diabetic patients with norinoalbuminuria, 27 type 2 diabetic patients with microalbuminuria, and 23 healthy controls were recruited. Serum levels of MMP-9, TIMP-1, and MMP9/NGAL complex were measured in all participants. Results. The MMP-9 level and MMP-9/TIMP-1 ratio were higher in patients with microalbuminuria when compared to the controls, while TIMP-1 level was lower (P = .005, P = .006, and P = .02, respectively). The MMP-9 level and MMP-9/TIMP-1 ratio were significantly higher in the patients with normoalbuminuria when compared to the controls (P = .005 and P = .02, respectively). In the normoalbuminuric patients, MMP-9 levels were negatively correlated with estimated GFR (r = -0.553, P = .008) and positively correlated with glucose (r = 0.449, P = .04), creatinine (r = 0.454, P = .03), and MMP9/NGAL complex (r = 0.575, P = .005). In the microalbuminuric patients, MMP-9 levels were positively correlated with total cholesterol (r = 0.430, P = .03), and MMP9/NGAL complex (r = 0.650, P = .001). Conclusions. The levels of MMP-9, TIMP-1, and MMP9/NGAL complex were similar in microalbuminuric and normoalbuminuric patients with type 2 diabetes mellitus. However, there was a significant MMP-9/TIMP-1 imbalance in both groups which may reflect impaired extracellular matrix homeostasis.en_US
dc.description.sponsorshipCoordination Office of Scientific Research Projects in Mustafa Kemal University, Turkey [15437]en_US
dc.description.sponsorshipThis study was supported by the Coordination Office of Scientific Research Projects in Mustafa Kemal University, Turkey (No, 15437).en_US
dc.identifier.endpage304en_US
dc.identifier.issn1735-8582
dc.identifier.issn1735-8604
dc.identifier.issue5en_US
dc.identifier.pmid30367022en_US
dc.identifier.startpage299en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9489
dc.identifier.volume12en_US
dc.identifier.wosWOS:000448436000008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherIranian Soc Nephrolgyen_US
dc.relation.ispartofIranian Journal of Kidney Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectdiabetic nephropathyen_US
dc.subjectmatrix metalloproteinase-9en_US
dc.subjecttissue inhibitor-1en_US
dc.subjectMMP-9/NGAL complexen_US
dc.subjectextracellular matrixen_US
dc.titleSerum Matrix Metalloproteinase-9, Tissue Inhibitor of Metalloproteinase-1 and Matrix Metalloproteinase-9/Neutrophil Gelatinase-associated Lipocalin Complex Levels in Patients with Early-stage Diabetic Nephropathyen_US
dc.typeArticleen_US

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