Antimicrobial Activity of Some Thiourea Derivatives and Their Nickel and Copper Complexes

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dc.authoridOZER, Cemal Koray/0000-0001-9957-4167
dc.authoridArslan, Hakan/0000-0003-0046-9442
dc.contributor.authorArslan, Hakan
dc.contributor.authorDuran, Nizami
dc.contributor.authorBorekci, Gulay
dc.contributor.authorOzer, Cemal Koray
dc.contributor.authorAkbay, Cevdet
dc.date.accessioned2024-09-18T20:59:24Z
dc.date.available2024-09-18T20:59:24Z
dc.date.issued2009
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractFive thiourea derivative ligands and their Ni2+ and Cu2+ complexes have been synthesized. The compounds were screened for their in vitro anti-bacterial activity using Gram-positive bacteria (two different standard strains of Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, Streptococcus pyogenes, Bacillus cereus) and Gram-negative bacteria (Esherichia coli, Pseudomonas aeruginosa, Enterobacter cloacae, Proteus vulgaris, Enterobacter aerogenes) and in vitro anti-yeast activity (Candida albicans, Candida krusei, Candida glabrata, Candida tropicalis, Candida parapsilosis). The minimum inhibitory concentration was determined for all ligands and their complexes. In vitro anti-yeast activity of both ligands and their metal complexes is greater than their in vitro anti-bacterial activity. The effect of the structure of the investigated compounds on the antimicrobial activity is discussed.en_US
dc.description.sponsorshipUSA National Institution of Health [P20 MD001089, S06 GM078246-01]; NCMHD; Department of Health and Human Servicesen_US
dc.description.sponsorshipSupport for this research was provided by grant P20 MD001089 and S06 GM078246-01 from the USA National Institution of Health, NCMHD, and Department of Health and Human Services.en_US
dc.identifier.doi10.3390/molecules14010519
dc.identifier.endpage527en_US
dc.identifier.issn1420-3049
dc.identifier.issue1en_US
dc.identifier.pmid19169199en_US
dc.identifier.scopus2-s2.0-59349086386en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage519en_US
dc.identifier.urihttps://doi.org/10.3390/molecules14010519
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12554
dc.identifier.volume14en_US
dc.identifier.wosWOS:000262791200041en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofMoleculesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectThiourea derivativesen_US
dc.subjectComplexesen_US
dc.subjectAntibacterial activityen_US
dc.subjectAntifungal activityen_US
dc.subjectIn vitro studiesen_US
dc.subjectLipophilicityen_US
dc.titleAntimicrobial Activity of Some Thiourea Derivatives and Their Nickel and Copper Complexesen_US
dc.typeArticleen_US

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