Protective Effect of Vitamin E and Melatonin Against Radiation Induced Damage in Testes of Rats

Basit Öğe Kaydı
dc.authoridGuven, Esref Oguz/0000-0003-4919-9383
dc.contributor.authorYalcinkaya, F. R.
dc.contributor.authorGokce, A.
dc.contributor.authorGuven, E. O.
dc.contributor.authorDavarci, M.
dc.contributor.authorCikim, G.
dc.contributor.authorYekeler, H.
dc.contributor.authorBalbay, M. D.
dc.date.accessioned2024-09-18T21:00:36Z
dc.date.available2024-09-18T21:00:36Z
dc.date.issued2009
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractTo investigate the effects of vitamin E and melatonin on gamma ray induced damage in testes of rats. A total of 40 Wistar type rats were divided into 4 groups, each including 10 rats. Total body radiation was applied to the first 3 groups with 90 cm, 90% isodose curve using Cobalt 60 apparatus. The period of exposure time was 11 min 30 see and a total of 360 cGy gamma radiation was administered in each session. Following radiation exposure, intraperitoneal injection of vitamin E (100 mg/kg/day), melatonin (100 mg/kg/day), 0.9% saline (100 mg/kg/day) were done in group 1-3, respectively. Group 4 was the control group and intraperitoneal 0.9% saline (100 mg/kg/day) was administered without any radiation. Five days after the procedure testes were removed and analyzed to measure Malondialdehyde (MDA) levels and degree of histopathological injury. Tissue MDA level measured in rats receiving melatonin did not show significant difference when compared to control group (p>0.05). Similarly, there was no significant tissue injury on histopathological examination between melatonin administered and control groups. However, compared to the control group both tissue MDA level and tissue injury were found to be significantly increased in groups, which received vitamin E and 0.9% saline solution (p<0.05). Melatonin displays a remarkable tissue protective effect by inhibiting the damage mediated by free radicals after radiation. The same effect could not be obtained with Vitamin E. Thus, the cytoprotective effect of melatonin can be of value in preserving testicular functions after radiation exposure.en_US
dc.identifier.endpage2340en_US
dc.identifier.issn1680-5593
dc.identifier.issue11en_US
dc.identifier.startpage2335en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12780
dc.identifier.volume8en_US
dc.identifier.wosWOS:000269800000045en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherMedwell Onlineen_US
dc.relation.ispartofJournal of Animal and Veterinary Advancesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectVitamin Een_US
dc.subjectmelatoninen_US
dc.subjectradiationen_US
dc.subjecttesticular damageen_US
dc.subjectoxidationen_US
dc.subjectmalondialdehydeen_US
dc.titleProtective Effect of Vitamin E and Melatonin Against Radiation Induced Damage in Testes of Ratsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu