Oxidative stress and antioxidant enzyme activities in patients with cutaneous leishmaniasis in endemic region of Hatay (Antioch)

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dc.authoridBerkoz, Mehmet/0000-0003-4219-8054
dc.authoridYALIN, Ali Erdinc/0000-0002-3351-6885
dc.contributor.authorCulha, Gulnaz
dc.contributor.authorYalin, Erdinc
dc.contributor.authorYalin, Serap
dc.contributor.authorEroglu, Pelin
dc.contributor.authorBerkoz, Mehmet
dc.date.accessioned2024-09-18T20:13:40Z
dc.date.available2024-09-18T20:13:40Z
dc.date.issued2007
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractLeishmania is the collective name for a number of disease caused by protozoon flagellates of genus Leishmania which have diverse clinical manifestations. In this study, we investigated the effect of free radicals and antioxidants on cutaneous leishmaniasis (CL). Venous blood samples of patients and controls were collected and analyzed for serum nitric oxide (NO) and malondialdehyde, (MDA) levels, superoxide dismutase (SOD) and catalase (CAT) activities. 53 treated CL patients, 42 untreated patients,and 30 healty control subjects were enrolled in this study. The levels of MDA and NO showed a significant increase (p < 0.05) in the untreated patients when compared to the treated patients and control groups. In the untreated group, the activities of both SOD and CAT were found to be decreased (p < 0.05) compared with values in the control and treated groups. After the treatment, NO and MDA levels were decreased whereas the activities of CAT and SOD were increased. These results provide some evidence for a potential role of increased lipid peroxidation and decreased enzymatic antioxidants in cutaneous leishmaniasis. These results suggested that oxidant stress plays an important role in the pathogenesis of cutaneous leishmaniasis.en_US
dc.identifier.endpage3118en_US
dc.identifier.issn0970-7077
dc.identifier.issn0975-427X
dc.identifier.issue4en_US
dc.identifier.startpage3113en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9315
dc.identifier.volume19en_US
dc.identifier.wosWOS:000251463400093en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherAsian Journal Of Chemistryen_US
dc.relation.ispartofAsian Journal of Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcutaneous leishmaniaen_US
dc.subjectlipid peroxidationen_US
dc.subjectantioxidanten_US
dc.subjectHatay (Antioch)en_US
dc.titleOxidative stress and antioxidant enzyme activities in patients with cutaneous leishmaniasis in endemic region of Hatay (Antioch)en_US
dc.typeArticleen_US

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