The Effect of Cape on Steroid Induced Osteonecrosis of the Femoral Head in Rat Model Hide

Basit Öğe Kaydı
dc.authoriddavut, serkan/0000-0003-3871-786X
dc.authoridAKDAG, ABDURRAHMAN/0000-0001-5292-8001
dc.authoridDokuyucu, Recep/0000-0001-6837-3477
dc.contributor.authorUruc, Vedat
dc.contributor.authorDuman, Ibrahim Gokhan
dc.contributor.authorDavul, Serkan
dc.contributor.authorOzden, Raif
dc.contributor.authorGonenci, Ramazan
dc.contributor.authorGokce, Hasan
dc.contributor.authorDokuyucu, Recep
dc.date.accessioned2024-09-18T20:06:27Z
dc.date.available2024-09-18T20:06:27Z
dc.date.issued2018
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe aim of this experimental study was to examine the effect of Caffeic acid phenethyl ester (CAPE) on steroid-induced osteonecrosis of femoral head (ONFH) in rats. Thirty-one male Wistar albino rats were divided into 4 groups: control group (7 rats), methylprednisolone treatment group (MPS, 8 rats), CAPE treatment group (8 rats) and MPS+CAPE administered group (8 rats). The rats of group MPS and CAPE+MPS, On days 2, 3 and 4 were treated with 20 mg/kg/day methylprednisolone (MPS; Pfizer Pharmaceutical, Puurs, Belgium) intramuscularly. 10 mu mol/kg/day CAPE was intraperitoneally injected to the rats of group CAPE from 13 weeks of age for 4 weeks. The control group was fed and housed under identical conditions without any treatment. All rats were sacrificed at 17 weeks of age by taking blood from the heart. Both proximal femoral parts were taken for histopathological and immunohistochemical analysis . Total oxidant status, total antioxidant status, and oxidative stress index (OSI), lipid parameters, coagulation parameters were assessed in blood specimens. Much lesser amount of osteonecrosis lesions were observed in the MPS+CAPE group compared to MPS group. In immunhisochemical analysis, oxidative stress was found significantly decreased in CAPE+MPS group compared to MPS group. OSI levels were significantly decreased in CAPE+MPS group compared to MPS group (p<0.001). In CAPE+MPS group lipid and coagulation parameters were found positively affected compared to MPS group. In conclusion, CAPE has strong protective effect against the steroid induced femoral head osteonecrosis in rats.en_US
dc.identifier.doi10.2485/jhtb.27.237
dc.identifier.endpage242en_US
dc.identifier.issn1341-7649
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85049962658en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage237en_US
dc.identifier.urihttps://doi.org/10.2485/jhtb.27.237
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8525
dc.identifier.volume27en_US
dc.identifier.wosWOS:000442562300011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherJournal Hard Tissue Biologyen_US
dc.relation.ispartofJournal of Hard Tissue Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCAPEen_US
dc.subjectFemoral head necrosisen_US
dc.subjectGlucocorticoiden_US
dc.subjectRaten_US
dc.titleThe Effect of Cape on Steroid Induced Osteonecrosis of the Femoral Head in Rat Model Hideen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Tam Metin / Full text
Boyut:
781 KB
Biçim:
Adobe Portable Document Format
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu