Effect of colchicine on polycystic ovary syndrome: an experimental study

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dc.authoridDokuyucu, Recep/0000-0001-7881-8871
dc.authoridDokuyucu, Recep/0000-0001-6837-3477
dc.authoridAKSOY, Ayse Nur/0000-0002-3793-9797
dc.contributor.authorGozukara, Ilay Ozturk
dc.contributor.authorPinar, Neslihan
dc.contributor.authorOzcan, Oguzhan
dc.contributor.authorOzgur, Tumay
dc.contributor.authorDokuyucu, Recep
dc.contributor.authorKurt, Raziye Keskin
dc.contributor.authorKucur, Suna Kabil
dc.date.accessioned2024-09-18T20:11:34Z
dc.date.available2024-09-18T20:11:34Z
dc.date.issued2016
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractPurpose To investigate whether there is any therapeutic effect of colchicine on a rat model of polycystic ovary syndrome (PCOS). Methods Twenty-two Wistar-Albino rats were randomly assigned into four with 8 rats in each group: control group; PCOS only group; PCOS-metformin group and PCOS-colchicine group. PCOS was induced by gavage with letrozole once daily at the concentration of 1 mg/kg orally with 21 consecutive days. After PCOS model assessment, PCOS-metformin group was received metformin orally with 500 mg/kg and PCOS-colchicine group was received colchicine orally with 1 mg/kg for the 35 day. Histopathology of ovaries, circulating estrone (E-1), estradiol (E-2), total testosterone, androstenedione and c-reactive protein (CRP) levels were evaluated. Results: cystic and atretic follicle number was significantly decreased, but CRP and hormone parameters were not significantly changed with colchicine treatment. Conclusion Colchicine has provided histopathological improvement compared with metformin in PCOS rat model.en_US
dc.description.sponsorshipDepartment of Scientific Research Project's in Mustafa Kemal Universityen_US
dc.description.sponsorshipThis work was done in Experimental Animal Laboratory of Mustafa Kemal University, Hatay, Turkey and supported by Department of Scientific Research Project's in Mustafa Kemal University.en_US
dc.identifier.doi10.1007/s00404-015-3933-5
dc.identifier.endpage680en_US
dc.identifier.issn0932-0067
dc.identifier.issn1432-0711
dc.identifier.issue3en_US
dc.identifier.pmid26525693en_US
dc.identifier.scopus2-s2.0-84958744483en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage675en_US
dc.identifier.urihttps://doi.org/10.1007/s00404-015-3933-5
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8948
dc.identifier.volume293en_US
dc.identifier.wosWOS:000372601200026en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofArchives of Gynecology and Obstetricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectColchicineen_US
dc.subjectPCOSen_US
dc.subjectMetforminen_US
dc.titleEffect of colchicine on polycystic ovary syndrome: an experimental studyen_US
dc.typeArticleen_US

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