Experimental hyperkalaemia in rabbits: Effects of salbutamol and norepinephrine treatments on blood biochemistry and electrocardiography

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dc.authoridBal, Ramazan/0000-0003-3829-8669
dc.contributor.authorCelik, S
dc.contributor.authorBal, R
dc.contributor.authorDurgut, R
dc.date.accessioned2024-09-18T20:27:55Z
dc.date.available2024-09-18T20:27:55Z
dc.date.issued2003
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe effects of salbutamol and norepinephrine on the electrocardiogram (ECG), serum potassium level and enzyme activities were studied in rabbits with hyperkalaemia; norepinephrine and salbutamol may be therapeutically useful. For induction of hyperkalaemia, 300 mM KCl solution was used and then isotonic saline solution containing 6 mug salbutamol and 3.9 mug norepinephrine per ml were administered. Norepinephrine and salbutamol decreased the serum potassium from 7.36 +/- 0.26 and 7.21 +/- 0.31 mmol/L to 5.62 +/- 0.27 and 4.35 +/- 0.33 mmol/L, respectively, and caused the ECG changes (flatness of P wave, widening of QRS complex and bradycardia) to return to the control conditions (time 0). Norepinephrine, but not salbutamol, decreased the activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and lactate dehydrogenase (LDH) to the control levels. These results suggest that monitoring of the enzyme activities might be useful as it yields indexes suitable for evaluating the therapeutic approach with norepinephrine in hyperkalaemia.en_US
dc.identifier.doi10.1556/AVet.51.2003.3.8
dc.identifier.endpage342en_US
dc.identifier.issn0236-6290
dc.identifier.issue3en_US
dc.identifier.pmid14516161en_US
dc.identifier.scopus2-s2.0-0042924201en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage331en_US
dc.identifier.urihttps://doi.org/10.1556/AVet.51.2003.3.8
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10603
dc.identifier.volume51en_US
dc.identifier.wosWOS:000185290100008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAkademiai Kiadoen_US
dc.relation.ispartofActa Veterinaria Hungaricaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjecthyperkalaemiaen_US
dc.subjectsalbutamolen_US
dc.subjectnorepinephrineen_US
dc.subjectbiochemistryen_US
dc.subjectelectrocardiographyen_US
dc.subjectrabbiten_US
dc.titleExperimental hyperkalaemia in rabbits: Effects of salbutamol and norepinephrine treatments on blood biochemistry and electrocardiographyen_US
dc.typeArticleen_US

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