Global validation of the WSES Sepsis Severity Score for patients with complicated intra-abdominal infections: a prospective multicentre study (WISS Study)

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dc.authoridCoccolini, Federico/0000-0001-6364-4186
dc.authoridMichalopoulos, Nickos/0000-0002-7740-4922
dc.authoridMarwah, Sanjay/0000-0002-0300-2779
dc.authoridChichom, Mefire Alain/0000-0001-7230-567X
dc.authoridMarinis, Athanasios/0000-0001-6423-6651
dc.authoridPereira, Jorge/0000-0002-3496-1710
dc.authoridISIK, ARDA/0000-0001-9493-4055
dc.contributor.authorSartelli, Massimo
dc.contributor.authorAbu-Zidan, Fikri M.
dc.contributor.authorCatena, Fausto
dc.contributor.authorGriffiths, Ewen A.
dc.contributor.authorDi Saverio, Salomone
dc.contributor.authorCoimbra, Raul
dc.contributor.authorOrdonez, Carlos A.
dc.date.accessioned2024-09-18T20:28:02Z
dc.date.available2024-09-18T20:28:02Z
dc.date.issued2015
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground: To validate a new practical Sepsis Severity Score for patients with complicated intra-abdominal infections (cIAIs) including the clinical conditions at the admission (severe sepsis/septic shock), the origin of the cIAIs, the delay in source control, the setting of acquisition and any risk factors such as age and immunosuppression. Methods: The WISS study (WSES cIAIs Score Study) is a multicenter observational study underwent in 132 medical institutions worldwide during a four-month study period (October 2014-February 2015). Four thousand five hundred thirty-three patients with a mean age of 51.2 years (range 18-99) were enrolled in the WISS study. Results: Univariate analysis has shown that all factors that were previously included in the WSES Sepsis Severity Score were highly statistically significant between those who died and those who survived (p < 0.0001). The multivariate logistic regression model was highly significant (p < 0.0001, R-2 = 0.54) and showed that all these factors were independent in predicting mortality of sepsis. Receiver Operator Curve has shown that the WSES Severity Sepsis Score had an excellent prediction for mortality. A score above 5.5 was the best predictor of mortality having a sensitivity of 89.2 %, a specificity of 83.5 % and a positive likelihood ratio of 5.4. Conclusions: WSES Sepsis Severity Score for patients with complicated Intra-abdominal infections can be used on global level. It has shown high sensitivity, specificity, and likelihood ratio that may help us in making clinical decisions.en_US
dc.identifier.doi10.1186/s13017-015-0055-0
dc.identifier.issn1749-7922
dc.identifier.pmid26677396en_US
dc.identifier.scopus2-s2.0-84949808332en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1186/s13017-015-0055-0
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10690
dc.identifier.volume10en_US
dc.identifier.wosWOS:000366547000001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBmcen_US
dc.relation.ispartofWorld Journal of Emergency Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIntra-abdominalen_US
dc.subjectInfectionsen_US
dc.subjectSepsisen_US
dc.subjectSeptic shocken_US
dc.titleGlobal validation of the WSES Sepsis Severity Score for patients with complicated intra-abdominal infections: a prospective multicentre study (WISS Study)en_US
dc.typeArticleen_US

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