The association of neutrophil/lymphocyte ratio and platelet/lymphocyte ratio with clinical outcomes in geriatric patients with stage 3-5 chronic kidney disease

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dc.authoridtatar, erhan/0000-0002-5068-4231
dc.contributor.authorTatar, Erhan
dc.contributor.authorMirili, Cem
dc.contributor.authorIsikyakar, Tolgay
dc.contributor.authorYaprak, Mustafa
dc.contributor.authorGuvercin, Guray
dc.contributor.authorOzay, Emine
dc.contributor.authorAsci, Gulay
dc.date.accessioned2024-09-18T20:08:26Z
dc.date.available2024-09-18T20:08:26Z
dc.date.issued2016
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective: The purpose of this study was to investigate the association of the neutrophil/lymphocyte ratio and platelet/lymphocyte ratio with the clinical outcomes in geriatric patients with stage 3-5 chronic kidney disease (CKD).Material and Methods: A total of 165 patients over the age of 65, with stage 3-5 CKD, were enrolled in the study. The primary endpoints were all-cause of deaths and requirement of renal replacement therapy. The patients were divided into two groups according to delta neutrophil/lymphocyte ratio such as increased (group 1) and decreased or stable (group 2) groups.Results: The mean age was 73.86.1years and the mean follow-up was 30 +/- 13months. Thirty-one (18.7%) patients died during the follow-up period and 21 (13.4%) patients required renal replacement therapy. The neutrophil/lymphocyte ratio increased in 95 (57.5%) patients. The mortality rate (24.2%, 11.4%; p=0.03) and requirement of renal replacement therapy (19.1%, 5.7%; p=0.01) were higher in group 1 compared to group 2. In the Cox regression analysis, the basal neutrophil/lymphocyte ratio was the independent predictor of death (HR: 1.23 (95% CI 1.02-1.47), p=0.02), and the basal eGFR was the independent predictor of requirement of renal replacement therapy (HR:0.938, 95% CI: 0.888-0.991, p=0.02). However, platelet/lymphocyte ratio was not associated with death and requirement of renal replacement therapy independently.Conclusion: The neutrophil/lymphocyte ratio predicts all-cause of mortality in geriatric patients with chronic kidney disease.en_US
dc.identifier.doi10.1080/17843286.2016.1159797
dc.identifier.endpage226en_US
dc.identifier.issn1784-3286
dc.identifier.issn2295-3337
dc.identifier.issue4en_US
dc.identifier.pmid27309205en_US
dc.identifier.scopus2-s2.0-84976313483en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage221en_US
dc.identifier.urihttps://doi.org/10.1080/17843286.2016.1159797
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8827
dc.identifier.volume71en_US
dc.identifier.wosWOS:000380152400004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofActa Clinica Belgicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChronic kidney diseaseen_US
dc.subjectGeriatric patienten_US
dc.subjectHemodialysisen_US
dc.subjectMortalityen_US
dc.subjectNeutrophilen_US
dc.subjectlymphocyte ratioen_US
dc.subjectPlateleten_US
dc.subjectlymphocyte ratioen_US
dc.titleThe association of neutrophil/lymphocyte ratio and platelet/lymphocyte ratio with clinical outcomes in geriatric patients with stage 3-5 chronic kidney diseaseen_US
dc.typeArticleen_US

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