CORRESPONDING ERDOSTEINE CHANGES AUTOPHAGY GENES EXPRESSION IN HIPPOCAMPUS ON RHINITIS MEDICAMENTOSA MODEL

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dc.authoridDokuyucu, Recep/0000-0001-7881-8871
dc.authoridDokuyucu, Recep/0000-0001-6837-3477
dc.contributor.authorDokuyucu, Recep
dc.contributor.authorGogebakan, Bulent
dc.contributor.authorCevik, Cengiz
dc.date.accessioned2024-09-18T20:55:49Z
dc.date.available2024-09-18T20:55:49Z
dc.date.issued2015
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractIn our study, rats were subjected to Oxymetazoline hydrochloride treatment and Rhinitis medicamentosa (RM) was formed and then autophagy gene expression levels were determined after the application of an antioxidant agent erdosteine (ED). The rats were divided into three groups; Group 1 was the control group. Group 2 (RM) and group 3 (RM+ED) rats received two spray puffs of 0.05% oxymetazoline into the nasal cavities three times daily for eight weeks. After determination of RM in the rats, the RM group were killed. The ED+RM group received 10 mg/kg of an ED suspension. At the end of seven days, these rats were also killed. All groups' hippocampus tissues were obtained for the measurement of autophagy gene expressions. In rhinitis medicamentosa group Atg5, Atg7 and Atg10 gene expressions in the left hippocampus were reduced as compared to control group (p=0.01, p>0.05, p=0.01, respectively). Also, erdosteine treatments were restored mRNA expression of autophagy genes. In right hippocampus of rhinitis medicamentosa group, Atg5 and Atg10 gene expressions was found to be down-regulated as compared to control group (p>0.05, p<0.05, respectively). Both BECN1 and ULK genes expression were found to be reduced in left hippocampus of rhinitis medicamentosa group. Erdosteine applications was restored the expression of these genes (p=0.03, p=0.03, respectively). Additionally, in right hippocampus, Erdosteine application was restored the expression of ULK gene (p=0.01). This is the first report that evaluated the expression autophagy genes in RM rat models and the changes observed after erdosteine applications.en_US
dc.identifier.doi10.2298/GENSR1503091D
dc.identifier.endpage1098en_US
dc.identifier.issn0534-0012
dc.identifier.issn1820-6069
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-84957091839en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1091en_US
dc.identifier.urihttps://doi.org/10.2298/GENSR1503091D
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12061
dc.identifier.volume47en_US
dc.identifier.wosWOS:000369703300028en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSerbian Genetics Socen_US
dc.relation.ispartofGenetika-Belgradeen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectRhinitis medicamentosaen_US
dc.subjectAutophagy genesen_US
dc.subjectHippocampusen_US
dc.subjectErdosteineen_US
dc.subjectOxymetazolineen_US
dc.titleCORRESPONDING ERDOSTEINE CHANGES AUTOPHAGY GENES EXPRESSION IN HIPPOCAMPUS ON RHINITIS MEDICAMENTOSA MODELen_US
dc.typeArticleen_US

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