Protective effects of Urtica dioica L. seed extract on liver tissue injury and antioxidant capacity in irradiated rats

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dc.authoridYENER, Zabit/0000-0002-6365-5843
dc.authoridYILDIZHAN, Kenan/0000-0002-6585-4010
dc.contributor.authorYildizhan, Kenan
dc.contributor.authorDemirtas, Omer Can
dc.contributor.authorUyar, Ahmet
dc.contributor.authorHuyut, Zubeyir
dc.contributor.authorCakir, Tahir
dc.contributor.authorKeles, Omer Faruk
dc.contributor.authorYener, Zabit
dc.date.accessioned2024-09-18T20:55:37Z
dc.date.available2024-09-18T20:55:37Z
dc.date.issued2020
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractRadiotherapy is often used for the treatment of cancer. However, it causes some side effects in patients. This study aimed to determine the hepatoprotective effects of Urtica dioica L. seed-extract (UDSE) in radiation-induced liver injury. Thirty-two male rats were randomly divided into 4 groups (n=8): control(C) group: no action was taken; radiation (R) group: irradiation was administrated at 5Gy single-fraction, radiation with UDSE(R+UDSE) group: irradiation was administrated at 5 Gy single-fraction and animals were fed pellets with 30 mL UDSE/kg; UDSE group: animals were fed pellets with 30 mL UDSE/kg. All of the experiments were performed in all of the groups over 10 days. Malondialdehyde (MDA) and reduced-glutathione (GSH) levels and superoxide-dismutase (SOD), catalase (CAT), glutathione-peroxidase (GSH-Px), aspartate-transaminase (AST), and alanine-aminotransferase (ALT) activities were detennined. Histopathological findings were also evaluated in liver tissues. SOD, CAT and GSH-Px activities and GSH levels in the serum and liver were significantly increased, while MDA levels decreased in the R+UDSE group compared with the R group (P<0.05). Moreover, AST and ALT serum activities in the R+UDSE group were lower than those in the R group (P<0.05). In addition, radiation induced degenerative/necrotic changes in the R group were significantly compensated in the R+UDSE group. The results showed that radiation increased oxidative stress and decreased antioxidant capacity, as well as degeneration in the liver. However, UDSE attenuated these degenerative changes.en_US
dc.description.sponsorshipDepartment of Biochemistry, Faculty of Medicine; Department of Pathology, Faculty of Veterinary, at the Van Yuzuncu Yil Universityen_US
dc.description.sponsorshipThis study was supported with the aid of the Department of Biochemistry, Faculty of Medicine and the Department of Pathology, Faculty of Veterinary, at the Van Yuzuncu Yil Universityen_US
dc.identifier.doi10.1590/s2175-97902019000318354
dc.identifier.issn1984-8250
dc.identifier.issn2175-9790
dc.identifier.scopus2-s2.0-85081680360en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1590/s2175-97902019000318354
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11956
dc.identifier.volume56en_US
dc.identifier.wosWOS:000521581500001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherUniv Sao Paulo, Conjunto Quimicasen_US
dc.relation.ispartofBrazilian Journal of Pharmaceutical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectRadiationen_US
dc.subjectUrtica dioica L.en_US
dc.subjectseed extracten_US
dc.subjectOxidative stressen_US
dc.subjectAntioxidanten_US
dc.subjectTissue injuryen_US
dc.titleProtective effects of Urtica dioica L. seed extract on liver tissue injury and antioxidant capacity in irradiated ratsen_US
dc.typeArticleen_US

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