Pharmacokinetics, Tissue Residues, and Withdrawal Times of Oxytetracycline in Rainbow Trout (Oncorhynchus mykiss) after Single- and Multiple-Dose Oral Administration

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dc.authoridUney, Kamil/0000-0002-8674-4873
dc.authoridTerzi, Ertugrul/0000-0003-2811-6497
dc.authoridCorum, Orhan/0000-0003-3168-2510
dc.contributor.authorCorum, Orhan
dc.contributor.authorDurna Corum, Duygu
dc.contributor.authorTerzi, Ertugrul
dc.contributor.authorUney, Kamil
dc.date.accessioned2024-09-18T19:54:29Z
dc.date.available2024-09-18T19:54:29Z
dc.date.issued2023
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractSimple Summary: Determination of the pharmacokinetics of oxytetracycline (OTC) at single and multiple oral doses revealed its long half-life, very low bioavailability, and strong accumulation in rainbow trout. The withdrawal time (WT) for the safe consumption of rainbow trout muscle+skin varied according to the guidelines set by regulatory authorities in different countries. This study improves the establishment of the optimal dosing regimen following OTC multiple administration and the determination of the appropriate WT for the safety of rainbow trout consumption. The aim of this study was to compare the pharmacokinetics of oxytetracycline (OTC) following single- (60 mg/kg) and multiple-dose oral administrations (60 mg/kg, every 24 h for 7 days) in rainbow trout. It also aimed to determine bioavailability after a single dose and tissue residues and withdrawal times after multiple doses. This study was carried out on 420 rainbow trout at 9 +/- 0.8 degrees C. This study was carried out in two stages: single-dose (intravascular and oral) and multiple-dose treatment. The OTC concentrations in plasma and tissues were measured by high-performance liquid chromatography and analyzed by a non-compartmental method. The withdrawal time (WT) was estimated using the WT 1.4 software. OTC exhibited a long terminal elimination half-life (t(1/2 lambda z)) after IV and oral administration. The oral bioavailability of OTC was very low (2.80%). In multiple-dose treatment, tt(1/2 lambda z), the area under the plasma concentrationtime curve and peak plasma concentration increased significantly after the last day compared to the first day. OTC showed strong accumulation after multiple doses with a value of 5.33. OTC concentrations were obtained in the order liver > kidney > muscle+skin > plasma. At 9 +/- 0.8 degrees C, the WT calculated for muscle+skin was 56 days for Europe and 50 days for China, respectively. The t(1/2 lambda z) (68.94 h) and time (68 h) above the 1 mu g/mL MIC following a single OTC dose may support the extension of the 24 h dosing interval following multiple dosing. However, further studies are required to determine the optimal dosage regimen in multiple-dose OTC treatment in the treatment of infections caused by susceptible pathogens.en_US
dc.description.sponsorshipCoordination of Scientific Research Projects, University of Selcuk, Trkiyeen_US
dc.description.sponsorshipNo Statement Availableen_US
dc.identifier.doi10.3390/ani13243845
dc.identifier.issn2076-2615
dc.identifier.issue24en_US
dc.identifier.pmid38136882en_US
dc.identifier.urihttps://doi.org/10.3390/ani13243845
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7764
dc.identifier.volume13en_US
dc.identifier.wosWOS:001135931500001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofAnimalsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectantibioticsen_US
dc.subjectaquacultureen_US
dc.subjectdrug residueen_US
dc.subjectfood safetyen_US
dc.subjectpublic healthen_US
dc.titlePharmacokinetics, Tissue Residues, and Withdrawal Times of Oxytetracycline in Rainbow Trout (Oncorhynchus mykiss) after Single- and Multiple-Dose Oral Administrationen_US
dc.typeArticleen_US

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