Lower LDL-cholesterol levels associated with increased inflammatory burden in patients with acute ST-segment elevation myocardial infarction

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dc.authoridAcikgoz, Eser/0000-0002-1775-1885
dc.authoridAcikgoz, Sadik Kadri/0000-0001-8241-4642
dc.contributor.authorAcikgoz, Eser
dc.contributor.authorAcikgoz, Sadik Kadri
dc.contributor.authorYaman, Belma
dc.contributor.authorKurtul, Alparslan
dc.date.accessioned2024-09-18T20:59:05Z
dc.date.available2024-09-18T20:59:05Z
dc.date.issued2021
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractOBJECTIVE: Association of low-density lipoprotein cholesterol and highly sensitive C-reactive protein in ST-elevation myocardial infarction patients was assessed in this study. METHODS: 591 consecutive patients who were hospitalized with a diagnosis of ST-elevation myocardial infarction were enrolled and assigned into tertiles according to their serum low-density lipoprotein cholesterol levels. Differences in highly sensitive C-reactive protein among low-density lipoprotein cholesterol tertiles and correlations between highly sensitive C-reactive protein and low-density lipoprotein cholesterol were assessed. RESULTS: Highly sensitive C-reactive protein levels differed significantly among the groups (p<0.001) and found to be highest in the low-density lipoprotein cholesterol tertile 1 and lowest in the low-density lipoprotein cholesterol tertile 3 (post-hoc p-values: tertile 1 vs. 2 <0.001; tertile 1 vs. 3 <0.001; tertile 2 vs. 3=0.019). There was a negative correlation between hs-CRP and both low-density lipoprotein cholesterol (r=-0.332, p<0.001) and total cholesterol (r=-0.326, p<0.001). There was also a negative correlation between highly sensitive C-reactive protein and high-density lipoprotein cholesterol, though the strength of this relationship was weak (r=-0.103, p=0.014). CONCLUSION: Lower low-density lipoprotein cholesterol levels are associated with higher inflammatory burden in patients with acute STEMI. Further studies are required to elucidate the significance of low-density lipoprotein cholesterol levels in ST-elevation myocardial infarction settings.en_US
dc.identifier.doi10.1590/1806-9282.67.02.20200548
dc.identifier.endpage229en_US
dc.identifier.issn1806-9282
dc.identifier.issue2en_US
dc.identifier.pmid34406246en_US
dc.identifier.scopus2-s2.0-85113321995en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage224en_US
dc.identifier.urihttps://doi.org/10.1590/1806-9282.67.02.20200548
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12364
dc.identifier.volume67en_US
dc.identifier.wosWOS:000686262400014en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAssoc Medica Brasileiraen_US
dc.relation.ispartofRevista Da Associacao Medica Brasileiraen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectST elevation myocardial infarctionen_US
dc.subjectCholesterolen_US
dc.subjectLDLen_US
dc.subjectHs-CRPen_US
dc.titleLower LDL-cholesterol levels associated with increased inflammatory burden in patients with acute ST-segment elevation myocardial infarctionen_US
dc.typeArticleen_US

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