Anti-inflammatory and antioxidant activity of thymoquinone in a rat model of acute bacterial prostatitis

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dc.authoridKaplan Sefil, Nebihat/0000-0003-0091-8471
dc.contributor.authorInci, M.
dc.contributor.authorDavarci, M.
dc.contributor.authorInci, M.
dc.contributor.authorMotor, S.
dc.contributor.authorYalcinkaya, F. R.
dc.contributor.authorNacar, E.
dc.contributor.authorAydin, M.
dc.date.accessioned2024-09-18T19:50:19Z
dc.date.available2024-09-18T19:50:19Z
dc.date.issued2013
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractProstatitis plays a major role in morbidity and mortality related to prostate diseases. The aim of this study was to detect whether thymoquinone (TQ) could ameliorate oxidative damage and the proliferative response induced by Escherichia coli (E. coli) in rats. A total of 42 adult male Wistar rats were used. The rats were randomly divided into seven groups (three treatment groups, three infected groups and one control group). Control group received saline and was killed 24 h after saline administration. Infected rats were killed after 24, 48 and 72 h following direct injection of E coli into the prostate. Treatment groups were administered with 10 mg/kg dose of TQ intraperitoneally following E. coli injection and after 24 and 48 h following E. coli injection. The rats were killed at 24, 48 and 72 h after the first drug administration. Each group was compared with each other and with the control group. In addition, infected groups were compared with treatment groups. Our findings show that the treatment with TQ has a protective effect against bacterial prostatitis-induced tissue injury. Increase in malondialdehyde levels and histological damage caused by E. coli were improved markedly with TQ treatment. TQ treatment particularly increased the activity of glutathione peroxidase and decreased the activities of catalase and superoxide dismutase. These observations might be attributed, at least in part, to the antioxidant effect of TQ and suggest that it could be a clinically valuable agent in the prevention of acute prostatitis caused by E. coli.en_US
dc.identifier.doi10.1177/0960327112455068
dc.identifier.endpage361en_US
dc.identifier.issn0960-3271
dc.identifier.issn1477-0903
dc.identifier.issue4en_US
dc.identifier.pmid22872606en_US
dc.identifier.scopus2-s2.0-84876724831en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage354en_US
dc.identifier.urihttps://doi.org/10.1177/0960327112455068
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7352
dc.identifier.volume32en_US
dc.identifier.wosWOS:000317806000003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofHuman & Experimental Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcute bacterial prostatitisen_US
dc.subjectthymoquinoneen_US
dc.subjectraten_US
dc.titleAnti-inflammatory and antioxidant activity of thymoquinone in a rat model of acute bacterial prostatitisen_US
dc.typeArticleen_US

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