Saffron induces Apoptosis in Ovarian Cancer cell via MAPK and AKT/mTOR Pathways

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dc.authoridASIL (Professor (Associate) ), HASAN/0000-0002-3690-1789
dc.contributor.authorOkyay, Ayse Guler
dc.contributor.authorKaplan, Hafil Mabir
dc.contributor.authorAsil, Hasan
dc.contributor.authorSingirik, Ergin
dc.date.accessioned2024-09-18T20:56:49Z
dc.date.available2024-09-18T20:56:49Z
dc.date.issued2020
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractStudy Objectives: Saffron and its main components have been shown to have anti-tumor and anticancer effects in animal studies and human cancer cell cultures. This study aimed to investigate the anti-cancer effects of saffron on human ovarian cancer cells. Methods: Powder of saffron was applied to the HO-8910 cell lines. Cell viability was determined. ELISA test is used to examine the activity of caspase-3 and expression of AIF, gadd153, grp78, caspase 3, bax, bcl-2, wee 1, which are apoptotic pathway's mediators. Active ERK (p-ERK), active INK (p-JNK) active AKT (p-AKT), and active mTOR (p-mTOR) were also analyzed by ELISA. Results: Saffron treatment reduced the viability of ovarian cancer cells. Saffron treatment increased activity of caspase 3 and expression of bax, wee 1, gadd153, grp78, and AIF and decreased bcl-2 which is anti-apoptotic protein. Saffron also decreased the activity of p-ERK, p-JNK, p-AKT, and p-mTOR in ovarian cancer cells. Conclusion: This study revealed that saffron has a beneficial effect on cancer treatment. Saffron may show a synergistic effect with various chemotherapeutics while directing the cancer cell to death. Crocetin, one of its active components, has shown a synergistic anti-cancer effect combined with cisplatin. Saffron induced apoptosis via ER stress, AKT/mTOR, and MAPK pathways in the ovarian cancer cell line.en_US
dc.identifier.doi10.23751/pn.v22i2-S.10160
dc.identifier.issn1129-8723
dc.identifier.scopus2-s2.0-85092756969en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.23751/pn.v22i2-S.10160
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12092
dc.identifier.volume22en_US
dc.identifier.wosWOS:000575795000001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherMattioli 1885en_US
dc.relation.ispartofProgress in Nutritionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSaffronen_US
dc.subjectovarian canceren_US
dc.subjectapoptosisen_US
dc.subjectMAPKen_US
dc.subjectAKT/mTORen_US
dc.titleSaffron induces Apoptosis in Ovarian Cancer cell via MAPK and AKT/mTOR Pathwaysen_US
dc.typeArticleen_US

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