Predictive Role of Blood Cellular Indices and Their Relationship with Endogenous Glycosaminoglycans as Determinants of Inflammatory Biomarkers in Pulmonary Embolism

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dc.authoridKacmaz, Murat/0000-0003-1111-8605
dc.authoridSiddiqui, Fakiha/0000-0002-2219-7049
dc.contributor.authorKantarcioglu, Bulent
dc.contributor.authorDarki, Amir
dc.contributor.authorSiddiqui, Fakiha
dc.contributor.authorKrupa, Emily
dc.contributor.authorVural, Mehmet
dc.contributor.authorKacmaz, Murat
dc.contributor.authorHoppensteadt, Debra
dc.date.accessioned2024-09-18T20:55:33Z
dc.date.available2024-09-18T20:55:33Z
dc.date.issued2022
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractIntroduction In this study, we profiled the levels of blood cellular indices, endogenous glycosaminoglycans (GAGs) and inflammatory biomarkers in a cohort comprised of pulmonary embolism (PE) patients, to determine their inter-relationships. Identification of this relationship may provide insight to the complex pathophysiology of PE and the predictive role of blood cellular indices in acute PE patients. Materials and Methods Plasma samples from PE patients and healthy controls were analyzed for thrombo-inflammatory biomarkers (IL-2, IL-4, IL-6, IL-8, IL-10, VEGF, IFN-gamma, TNF-alpha, IL-1 alpha, IL-1 beta, MCP-1, EGF, D-dimer, CRP and MMP-9) using biochip array and ELISA methods. The endogenous GAG levels were quantified using a fluorescence quenching method. The data regarding the blood cellular indices were collected through the review of patient medical records and analyzed to demonstrate their relationship. Results The levels of inflammatory biomarkers and endogenous GAGs were elevated in acute PE patients compared to controls (P < .05). Most of the blood cellular indices have shown significant differences in acute PE patients compared to controls (P < .05). The levels of inflammatory biomarkers, endogenous GAGs and the blood cellular indices have shown significant associations in correlation and multivariable analysis. While NLR, PLR and SII were significantly predicting the 30-day mortality, PNR, ELR and EMR were not sufficient to predict 30-day mortality in acute PE. Conclusion Our results show that the increased thrombo-inflammatory response is associated with the release of GAGs and the changes in blood cellular indices. The predictive role of the blood cellular indices for mortality is dependent on their relationship with the inflammatory response.en_US
dc.description.sponsorshipCambridge Scientific, Boston, Mass, USAen_US
dc.description.sponsorshipThe authors gratefully acknowledge the skillful assistance of the Cardiology Division fellows and supportive staff in facilitating the study. We are also thankful to the staff of the clinical lab and Hemostasis Research Unit for their assistance during the study. We are thankful to Dr Seth Robia and Dr Alain Heroux, Co-directors of Cardiovascular Research Institute and Dr Lowell Steen for their support and guidance. Special thanks to Dr Meharvan Singh, Vice Provost of Research, for his encouragement and endorsement of the study. We also acknowledge Mr Jonas Kingo and Ms. Catherine Sandon for providing some of the kits used in the study. A special thanks to Professor Roland Kramer of the Institute of Inorganic Chemistry, Heidelberg University for providing the heparin red reagent and guidance in completing this study. This study was partially supported from a grant from Cambridge Scientific, Boston, Mass, USA. We also acknowledge the skillful assistance of Ms. Erin Healy-Erickson in preparing this manuscript.en_US
dc.identifier.doi10.1177/10760296221104801
dc.identifier.issn1076-0296
dc.identifier.issn1938-2723
dc.identifier.pmid35733366en_US
dc.identifier.scopus2-s2.0-85132642838en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1177/10760296221104801
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11913
dc.identifier.volume28en_US
dc.identifier.wosWOS:000816431000001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofClinical and Applied Thrombosis-Hemostasisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectpulmonary embolismen_US
dc.subjectinflammatory biomarkersen_US
dc.subjectendogenous glycosaminoglycansen_US
dc.subjectblood cellular indicesen_US
dc.subjectCOVID-19en_US
dc.titlePredictive Role of Blood Cellular Indices and Their Relationship with Endogenous Glycosaminoglycans as Determinants of Inflammatory Biomarkers in Pulmonary Embolismen_US
dc.typeArticleen_US

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