Protective Effects of Alpha-Lipoic Acid on Oleic Acid-Induced Acute Lung Injury in Rats

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dc.authoridGULCU BULMUS, Funda/0000-0002-2514-4559
dc.authoridGURSU, M.Ferit/0000-0003-3552-7315
dc.contributor.authorBulmus, Funda Gulcu
dc.contributor.authorGursu, Mehmet Ferit
dc.contributor.authorMuz, Mehmet Hamdi
dc.contributor.authorYaman, Ihsan
dc.contributor.authorBulmus, Ozgur
dc.contributor.authorSakin, Fatih
dc.date.accessioned2024-09-18T19:50:20Z
dc.date.available2024-09-18T19:50:20Z
dc.date.issued2013
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground: Oxidative stress is believed to be an important factor in the pathogenesis of acute lung injury (ALI). Aims: The aim of this study was to investigate the possible protective role of alpha-lipoic acid (alpha-LA) on oleic acid (OA)-induced ALI in rats. Study Design: Animal experiment. Methods: A total of thirty-five rats were divided into five groups in the study. Group 1 served as a control group. Rats in Group 2 (alpha-LA) were administered alpha-LA intraperitoneally at a dose of 100 mg/kg body weight (SW). Rats in Group 3 (OA) were administered OA intravenously at a dose of 100 mg/kg BW. In Group 4 (pre-OA-alpha-LA), alpha-LA was given 15 minutes prior to OA infusion, and in Group 5 (post-OA-alpha-LA), alpha-LA was given two hours after OA infusion. Four hours after the OA infusion, rats were decapitated. Blood samples were collected to measure serum levels of malondialdehyde (MDA) and glutathione (GSH), and the levels of activity for superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px). Lung tissue samples were taken for histopathological examination. Results: Exposure to OA resulted in increases in serum MDA levels (p<0.001), as well as histopathological lesions in lung tissue, and decreases in CAT (p<0.05), GSH-Px (p<0.05) activities and GSH (p<0.05) levels. On the other hand, MDA levels were decreased significantly (p<0.001), while CAT (p<0.05), GSH-Px (p<0.01) activities and GSH (p<0.05) levels were increased significantly in the pre-OA-alpha-LA group compared with the OA group. Conclusion: alpha-LA was found to lessen oxidative stress and to have positive effects on antioxidants in cases of OA-induced ALI. In conclusion, alpha-LA appears to have protective effects against ALI and potential for the prevention of ALI.en_US
dc.description.sponsorshipFirat University Scientific Research Projects Unit (FUBAP) [1402]en_US
dc.description.sponsorshipThis study was supported by the Firat University Scientific Research Projects Unit (FUBAP), project number 1402.en_US
dc.identifier.doi10.5152/balkanmedj.2013.8426
dc.identifier.endpage314en_US
dc.identifier.issn2146-3123
dc.identifier.issn2146-3131
dc.identifier.issue3en_US
dc.identifier.pmid25207126en_US
dc.identifier.startpage309en_US
dc.identifier.urihttps://doi.org/10.5152/balkanmedj.2013.8426
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7369
dc.identifier.volume30en_US
dc.identifier.wosWOS:000324603300012en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofBalkan Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcute lung injuryen_US
dc.subjectoleic aciden_US
dc.subjectalpha-lipoic aciden_US
dc.subjectoxidative stressen_US
dc.titleProtective Effects of Alpha-Lipoic Acid on Oleic Acid-Induced Acute Lung Injury in Ratsen_US
dc.typeArticleen_US

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