Effect of Hypericum thymbrifolium BOISS. ET NOE, Hypericum scabrum L. and Eryngium creticum LAM. plant extracts on Leishmania major, Leishmania tropica and Leishmania infantum/donovani strains and their cytotoxic potential

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dc.contributor.authorOzpinar, H.
dc.contributor.authorCulha, G.
dc.contributor.authorOzpinar, N.
dc.contributor.authorKaya, T.
dc.contributor.authorKara, B.
dc.contributor.authorYucel, H.
dc.date.accessioned2024-09-18T19:54:32Z
dc.date.available2024-09-18T19:54:32Z
dc.date.issued2024
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractLeishmaniasis causes significant morbidity and mortality worldwide. In our country, there has been a significant increase in the number of cases of leishmaniasis in the last decade. In our study, the effects of Hypericum thymbrifolium, Hypericum scabrum and Eryngium creticum plant extracts were tested on Leishmania major, Leishmania tropica and Leishmania infantum/donovani, which were clinically resistant by not responding to Glucantime (R) therapy. Cytotoxicity of these extracts were evaluated by XTT method in the human fibroblast cell line. Possible active ingredients were detected by GC-MS analysis from plant extracts. Glucantime (R) resistance was detected at concentrations of 50 p.g/mL and lower in 4 of the 7 strains tested. No living leishmania parasites were found in leishmania strains treated with plant extracts at concentrations of 100 p.g/mL or higher. The concentrations of plant extracts included in the study on the WI-38 human fibroblast cell line were not cytotoxic. According to the GC-MS analysis, several active substances with biological activities and anti-parasitic effects, such as Thiophene, Germacrene-D, trans-Geranylgeraniol, Pyridine, and Maleimides, were identified. Based on the findings of the study, it is believed that these identified active substances when supported by in-vivo studies, will pave the way for future research and have the potential to be developed as anti-leishmania drugs.en_US
dc.description.sponsorshipHatay Mustafa Kemal University Scientific Research Projects Coordination Unit; [20.M.024]en_US
dc.description.sponsorshipThis study was supported by Hatay Mustafa Kemal University Scientific Research Projects Coordination Unit (Project number: 20.M.024) .en_US
dc.identifier.doi10.47665/tb.41.1.005
dc.identifier.endpage44en_US
dc.identifier.issn0127-5720
dc.identifier.issue1en_US
dc.identifier.pmid38852132en_US
dc.identifier.scopus2-s2.0-85194355130en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage36en_US
dc.identifier.urihttps://doi.org/10.47665/tb.41.1.005
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7785
dc.identifier.volume41en_US
dc.identifier.wosWOS:001219428900001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMalaysian Soc Parasitology Tropical Medicineen_US
dc.relation.ispartofTropical Biomedicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnti-leishmanial activityen_US
dc.subjectH. thymbrifoliumen_US
dc.subjectH. scabrumen_US
dc.subjectEryngium creticum .en_US
dc.titleEffect of Hypericum thymbrifolium BOISS. ET NOE, Hypericum scabrum L. and Eryngium creticum LAM. plant extracts on Leishmania major, Leishmania tropica and Leishmania infantum/donovani strains and their cytotoxic potentialen_US
dc.typeArticleen_US

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