Re-Protective Effects of Pre- and Post-Laparoscopy Conditioning, Zinc, Pentoxifylline, and N-acetylcysteine in an Animal Model of Laparoscopy-Induced Ischemia/Reperfusion Injury of the Kidney

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dc.authoridOzkan, Orhan Veli/0000-0002-2862-294X
dc.authorid/0000-0002-1807-6957
dc.contributor.authorOksuz, Hafize
dc.contributor.authorBulbuloglu, Ertan
dc.contributor.authorSenoglu, Nimet
dc.contributor.authorCiralik, Harun
dc.contributor.authorYuzbasioglu, M. Fatih
dc.contributor.authorKilinc, Metin
dc.contributor.authorDogan, Zafer
dc.date.accessioned2024-09-18T20:28:17Z
dc.date.available2024-09-18T20:28:17Z
dc.date.issued2009
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground. Pneumoperitoneum (P) created to facilitate laparoscopy (L) is associated with splanchnic hypoperfusion, ischemia/reperfusion (I/R) injury, and oxidative stress. Aim. This study investigated the effects of pre- and post-laparoscopic conditioning, zinc, pentoxifylline (PTX), and N-acetylcysteine (NAC) on markers of I/R injury in an animal model. Methods. Sprague-Dawley male rats (n = 56, weight range 300-350 g) were randomly placed in one of seven treatment groups. Except for group C (control group who underwent a sham operation without pneumoperitoneum), pneumoperitoneum was created in all using CO2 insufflation under a pressure of 15 mmHg. Group L (laparoscopy) was subjected to 60 min of pneumoperitoneum. Group Lpre (laparoscopic preconditioning plus laparoscopy) was subjected to 5 min of insufflation and 5 min of desufflation followed by 60 min of pneumoperitoneum. Group Lpost (laparoscopy plus laparoscopic post-conditioning) was subjected to 60 min of pneumoperitoneum and 60 min of desufflation followed by 5 min of insufflation and 5 min of desufflation. The laparoscopy plus zinc (LZ), PTX (LP), and NAC (LNAC) groups received a single intraperitoneal injection of zinc (50 mg/kg), pentoxifylline (50 mg/kg), or N-acetylcysteine (150 mg/kg) 5 min before the desufflation period. Animals were sacrificed at the end of the experiments, and kidney samples were tested for malondialdehyde (MDA), catalase (CAT), glutathione peroxidase (GPX), and superoxide dismutase (SOD). Results. MDA levels, as an indicator of oxidative stress in kidney tissue samples, were significantly higher in all pneumoperitoneum groups compared to Group C, except for Group Lpre. The pattern of change in tissue levels of SOD, GPX, and catalase was variable in the different treatment groups. Conclusions. In this animal model of renal ischemia/reperfusion injury, laparoscopy caused renal ischemia as evidenced by elevated markers of tissue ischemia-reperfusion injury. This effect was significantly attenuated by post-laparoscopy conditioning, zinc, pentoxifylline, and N-acetylcysteine, but not by pre-laparoscopy conditioning.en_US
dc.identifier.doi10.1080/08860220902780044
dc.identifier.endpage302en_US
dc.identifier.issn0886-022X
dc.identifier.issn1525-6049
dc.identifier.issue4en_US
dc.identifier.pmid19462279en_US
dc.identifier.scopus2-s2.0-67651154199en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage297en_US
dc.identifier.urihttps://doi.org/10.1080/08860220902780044
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10826
dc.identifier.volume31en_US
dc.identifier.wosWOS:000266279700008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofRenal Failureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectkidneyen_US
dc.subjectischemiaen_US
dc.subjectreperfusion injuryen_US
dc.subjectoxidative stressen_US
dc.subjectpneumoretroperitoneumen_US
dc.subjectzincen_US
dc.titleRe-Protective Effects of Pre- and Post-Laparoscopy Conditioning, Zinc, Pentoxifylline, and N-acetylcysteine in an Animal Model of Laparoscopy-Induced Ischemia/Reperfusion Injury of the Kidneyen_US
dc.typeArticleen_US

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