Effects of montelukast and methylprednisolone on experimental spinal cord injury in rats

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dc.authoridCAVUS, GOKHAN/0000-0001-7078-2501
dc.authoridSefil, Fatih/0000-0001-5534-7448
dc.contributor.authorCavus, G.
dc.contributor.authorAltas, M.
dc.contributor.authorAras, M.
dc.contributor.authorOzgur, T.
dc.contributor.authorSerarslan, Y.
dc.contributor.authorYilmaz, N.
dc.contributor.authorSefil, F.
dc.date.accessioned2024-09-18T20:29:50Z
dc.date.available2024-09-18T20:29:50Z
dc.date.issued2014
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractOBJECTIVE: The development of secondary brain injury after trauma is known to involve in many cellular mediators. The aim of the study was to evaluate and compare the effects of the use of both methylprednisolone and montelukast on serum and tissue concentrations of NO, malondialdehyde (MDA) levels, superoxide dismutase (SOD) activity, and tissue glutathione peroxidase (GSH-Px) activity in rats with spinal cord injury (SCI). MATERIALS AND METHODS: SCI was induced in Wistar albino rats by dropping a 10 g rod from a 5.0 cm height at T9-10. The 28 rats were randomly divided into four equal groups: montelukast, methylprednisolone, non-treatment and sham groups. Rats were neurologically tested at 24 hours after trauma and spinal cord tissue levels of MDA, SOD, GSH-PX, CAT levels and blood CK, CK-BB, LDH levels were measured. In addition, histopathological changes were also examined. RESULTS: There was a significant improvement in Tarlov scores in methylprednisolone and montelukast administered group compared to the trauma group (p = 0.001). When compared to trauma group, methylprednisolone and montelukast groups had significant differences in MDA (p < 0.05), SOD (p < 0.001), CK-BB (p < 0.001) and LDH (p < 0.05) levels. Histopathologically, no significant changes were observed. CONCLUSIONS: The present study shows effects of montelukast with biochemical and histopathological parameters and compares its effects with those of methylprednisolone for the first time. Our research has shown that montelukast and methylprednisolone have a neuroprotective effect on spinal cord injury.en_US
dc.identifier.endpage1777en_US
dc.identifier.issn1128-3602
dc.identifier.issue12en_US
dc.identifier.pmid24992621en_US
dc.identifier.scopus2-s2.0-84926132472en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1770en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11080
dc.identifier.volume18en_US
dc.identifier.wosWOS:000341975800018en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMedulla spinalisen_US
dc.subjectSpinal traumaen_US
dc.subjectMethylprednisoloneen_US
dc.subjectMontelukasten_US
dc.subjectSuperoxide dismutaseen_US
dc.subjectMalondialdehydeen_US
dc.titleEffects of montelukast and methylprednisolone on experimental spinal cord injury in ratsen_US
dc.typeArticleen_US

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