Combination of infra-red light with nanogold targeting macrophages in the treatment of Leishmania major infected BALB/C mice

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dc.authoridTosun, Mustafa/0000-0002-6189-8016
dc.authoridCam, Selim/0000-0002-6131-2871
dc.contributor.authorGuner, Rukiye Yasak
dc.contributor.authorHayta, Sibel Berksoy
dc.contributor.authorTosun, Mustafa
dc.contributor.authorAkyol, Melih
dc.contributor.authorOzpinar, Necati
dc.contributor.authorPolat, Zubeyde Akin
dc.contributor.authorEgilmez, Reyhan
dc.date.accessioned2024-09-18T20:13:41Z
dc.date.available2024-09-18T20:13:41Z
dc.date.issued2022
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractPurpose In the treatment of cutaneous leishmaniasis (CL), developing drug resistance, existing toxic effects of drugs and failure respond to treatment cause the need to try different treatment methods. We investigated the effect of gold-conjugated macrophage-specific antibody on amastigotes under infra-red light for the treatment of CL. Methods Female BALB/c (4-8 weeks old, 20 +/- 5 g weight) mice were used in the study. The L. major strain was inoculated on the soles of mice in amastigote form and subpassed. Nanogold (Au), Au + macrophage-specific antibody (MSA) modification and near infra-red (NIR) (5 seconds) were applied to mice groups that developed cutaneous leishmaniasis on their soles. On the 5th and 10th days of the treatment, the lesions were examined clinically and pathologically. Results When the erythema values were examined, the highest decrease was calculated in the Au + MSA + NIR group in the measurements made on the 10(th) day (p < 0.014). The best improvement in 10(th) day measurements is in the NIR and Au + MSA + NIR groups when area values were examined (p = 0.011, p = 0.001). There was a statistically significant difference between the groups in terms of parasite load (PL) (p < 0.005) in pathological evaluation. According to PL grouping, the best result is NIR (p = 0.002). When both main titles (clinical and pathological) are examined, the Au + MSA + NIR group is thought to have an optimal therapeutical feature. Conclusions Au + MSA + NIR combination could be a new treatment approach for CL treatment.en_US
dc.description.sponsorshipSivas Cumhuriyet University Scientific Research Projects Commissionen_US
dc.description.sponsorshipSivas Cumhuriyet University Scientific Research Projects Commission.en_US
dc.identifier.doi10.1080/15569527.2021.2000430
dc.identifier.endpage24en_US
dc.identifier.issn1556-9527
dc.identifier.issn1556-9535
dc.identifier.issue1en_US
dc.identifier.pmid35100933en_US
dc.identifier.scopus2-s2.0-85124266075en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage18en_US
dc.identifier.urihttps://doi.org/10.1080/15569527.2021.2000430
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9321
dc.identifier.volume41en_US
dc.identifier.wosWOS:000749349700001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofCutaneous and Ocular Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcutaneous leishmaniasisen_US
dc.subjectnanogolden_US
dc.subjectBALBen_US
dc.subjectcen_US
dc.subjectphototherapyen_US
dc.subjectmacrophage-specific antibodyen_US
dc.titleCombination of infra-red light with nanogold targeting macrophages in the treatment of Leishmania major infected BALB/C miceen_US
dc.typeArticleen_US

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