Chronic obstructive pulmonary disease may be one of the terminal endpoints of the sickle cell diseases

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dc.contributor.authorHelvaci, Mehmet Rami
dc.contributor.authorDogru, Sibel
dc.date.accessioned2024-09-18T20:57:02Z
dc.date.available2024-09-18T20:57:02Z
dc.date.issued2015
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground: Sickle cell diseases (SCDs) are chronic destructive processes on vascular endothelium initiating at birth all over the body. We tried to understand whether or not there is an association between chronic obstructive pulmonary disease (COPD) and severity of the SCDs. Methods: All patients with the SCDs were taken into the study. Results: The study included 411 patients with the SCDs (199 females and 212 males). There were 60 patients (14.5%) with the COPD. Mean age of the patients was significantly higher in the COPD group (33.0 versus 29.5 years, P=0.005). The male ratio was significantly higher in the COPD group, too (80.0% versus 46.7%, P<0.001). Smoking was also higher in the COPD group, significantly (36.6% versus 9.9%, P<0.001). Parallel to the smoking, alcoholism was also higher among the COPD cases, significantly (3.3% versus 0.8%, P<0.05). Beside these, transfused red blood cell units in their lives (69.1 versus 32.9, P=0.001), priapism (10.0% versus 1.9%, P<0.001), leg ulcers (26.6% versus 11.6%, P<0.001), digital clubbing (25.0% versus 7.1%, P<0.001), coronary heart disease (26.6% versus 13.1%, P<0.01), chronic renal disease (16.6% versus 7.1%, P<0.01), and stroke (20.0% versus 7.9%, P<0.001) were all higher among the COPD cases, significantly. Conclusion: SCDs are chronic catastrophic processes on vascular endothelium particularly at the capillary level, and terminate with accelerated atherosclerosis induced end-organ failures in early years of life. COPD may be one of the terminal endpoints of the diseases.en_US
dc.identifier.endpage17en_US
dc.identifier.issn1839-0188
dc.identifier.issn1839-0196
dc.identifier.issue8en_US
dc.identifier.startpage11en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12250
dc.identifier.volume13en_US
dc.identifier.wosWOS:000385839400003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherMedi+World Inten_US
dc.relation.ispartofWorld Family Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSickle cell diseasesen_US
dc.subjectchronic obstructive pulmonary diseaseen_US
dc.subjectchronic endothelial damageen_US
dc.titleChronic obstructive pulmonary disease may be one of the terminal endpoints of the sickle cell diseasesen_US
dc.typeArticleen_US

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