Investigating virulence factors of clinical Candida isolates in relation to atmospheric conditions and genotype

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dc.contributor.authorInci, Melek
dc.contributor.authorAtalay, Mustafa Altay
dc.contributor.authorKoc, Ayse Nedret
dc.contributor.authorYula, Erkan
dc.contributor.authorEvirgen, Omer
dc.contributor.authorDurmaz, Suleyman
dc.contributor.authorDemir, Gonca
dc.date.accessioned2024-09-18T20:06:25Z
dc.date.available2024-09-18T20:06:25Z
dc.date.issued2012
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractAim: To investigate some virulence factors in Candida species isolated from patients with suspected invasive fungal infection and to identify their relationship with Candida genotypes. Materials and methods: Overall 45 isolates (20 Candida albicans and 25 non-albicans Candida spp.) genotyped by rep-PCR were included in this study. Virulence factors were studied in both aerobic and anaerobic conditions. In isolates, egg yolk agar was used for determining phospholipase activity, while bovine serum albumin agar was used for proteinase activity, Tween-80 medium for esterase activity, and Sabouraud dextrose agar with sheep blood for hemolysin activity. Biofilm formation was detected by the microplate method. Results: In both Candida spp., it was found that hemolytic activity and proteinase activity were higher in aerobic conditions, whereas biofilm formation was higher in anaerobic conditions. It was also found that phospholipase and esterase activity were only detected in C. albicans isolates, which were found to be higher in aerobic conditions. No difference was found in virulence factors evaluated among the C. albicans genotypes. Conclusion: The amount of oxygen in the atmosphere may affect the virulence of Candida spp. Further comprehensive studies are needed in order to identify the relationship between Candida genotypes and virulence factors.en_US
dc.identifier.doi10.3906/sag-1204-119
dc.identifier.endpage1483en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.scopus2-s2.0-84870726436en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1476en_US
dc.identifier.urihttps://doi.org/10.3906/sag-1204-119
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8510
dc.identifier.volume42en_US
dc.identifier.wosWOS:000321226500019en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technological Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCandida spp.en_US
dc.subjectvirulence factorsen_US
dc.subjectatmospheric conditionen_US
dc.subjectgenotypeen_US
dc.titleInvestigating virulence factors of clinical Candida isolates in relation to atmospheric conditions and genotypeen_US
dc.typeArticleen_US

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