Effects of valproic acid on hearing in epileptic patients

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dc.authoridDUMAN, Taskin/0000-0002-6552-4193
dc.authoridSangun, Ozlem/0000-0002-9079-4574
dc.contributor.authorIncecik, Faruk
dc.contributor.authorAkoglu, Ertap
dc.contributor.authorSanguen, Zlem
dc.contributor.authorMelek, Ismet
dc.contributor.authorDuman, Taskin
dc.date.accessioned2024-09-18T21:00:32Z
dc.date.available2024-09-18T21:00:32Z
dc.date.issued2007
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective: Since some case reports about the ototoxicity of valproic acid have been published, probable adverse effects of valproic acid on hearing in the epileptic patients became a subject of interest. We wanted to investigate if ototoxicity occurs in pediatric epileptic patients using VPA for long terms. Methods: Twenty-one epileptic patients who have been using valproic acid at least for 6 months as monotherapy and 21 age-sex matched controls were included in the study. Audiometric tests were performed to all patients between the frequencies of 125 and 16,000 Hz. The effects of dosage, duration of therapy and serum levels of the VPA, on the audiometric results were investigated and the audiometric results were compared between the groups. Results: There was no difference in hearing thresholds of the groups between 125 and 16,000 Hz frequencies. Relation could not be established between the duration of VPA therapy, dosage of the drug, blood level of drug, age and sex of the patients and the auditory signs. Conclusions: Although we could not find any deleterious effect of VPA on hearing thresholds in our patient series, we think it is useful to perform audiometric tests at intervals while VPA is being used for tong periods, considering the presented case reports about sensorineural hearing loss. (c) 2007 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.ijporl.2006.12.011
dc.identifier.endpage614en_US
dc.identifier.issn0165-5876
dc.identifier.issn1872-8464
dc.identifier.issue4en_US
dc.identifier.pmid17270285en_US
dc.identifier.scopus2-s2.0-33847661920en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage611en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijporl.2006.12.011
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12742
dc.identifier.volume71en_US
dc.identifier.wosWOS:000245418000016en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofInternational Journal of Pediatric Otorhinolaryngologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectvalproic aciden_US
dc.subjectside effectsen_US
dc.subjecthearing lossen_US
dc.titleEffects of valproic acid on hearing in epileptic patientsen_US
dc.typeArticleen_US

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