The Protective Effect of Ebselen on Radiocontrast-Induced Nephrotoxicity

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dc.contributor.authorOzgur, Tumay
dc.contributor.authorTutanc, Murat
dc.contributor.authorZararsiz, Ismail
dc.contributor.authorMotor, Sedat
dc.contributor.authorOzturk, Oktay Hasan
dc.contributor.authorYaldiz, Mehmet
dc.contributor.authorKurtgoz, Ozgur Yildirim
dc.date.accessioned2024-09-18T20:55:37Z
dc.date.available2024-09-18T20:55:37Z
dc.date.issued2012
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractAim: Radiocontrast-induced nephropathy has become one of the most important causes of renal acute failure. The most effective management of reducing the incidence of contrast nephropathy is to understand and prevent its causes. We aimed to investigate the protective role of ebselen against radiocontrast-induced nephrotoxicity in terms of tissue oxidant/antioxidant parameters and light microscopy in rats. Methods: Albino Wistar rats were randomly separated into four groups. The Group 1 rats were treated with sodium chloride as the control group, Group 2 with radiocontrast, Group 3 with radiocontrast plus ebselen, and Group 4 with ebselen alone. After 24 h, the animals over the experimental period were euthanized and blood samples were analyzed for blood urea nitrogen (BUN) and serum creatinine (Cr) levels. Kidney sections were analyzed for malondialdehyde (MDA) levels and superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities, as well as histopathological changes. Results: In the radiocontrast group, BUN, MDA, and GSH-Px levels increased while SOD activity decreased compared with the control group. These decays were improved by ebselen administration in the radiocontrast group. Significant histological deteriorations were observed in the radiocontrast group. We noted improvement in the histologic findings with ebselen administration. Conclusion: These results indicate that ebselen might produce a protective mechanism against radiocontrast-induced nephrotoxicity.en_US
dc.description.sponsorshipMustafa Kemal University Scientific Research Project Board [1202M0111]en_US
dc.description.sponsorshipThis study was supported by Mustafa Kemal University Scientific Research Project Board with project number 1202M0111.en_US
dc.identifier.doi10.3109/0886022X.2012.706880
dc.identifier.endpage997en_US
dc.identifier.issn0886-022X
dc.identifier.issn1525-6049
dc.identifier.issue8en_US
dc.identifier.pmid22880804en_US
dc.identifier.scopus2-s2.0-84865266098en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage991en_US
dc.identifier.urihttps://doi.org/10.3109/0886022X.2012.706880
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11961
dc.identifier.volume34en_US
dc.identifier.wosWOS:000307438300009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofRenal Failureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectradiocontrasten_US
dc.subjectebselenen_US
dc.subjectnephrotoxicityen_US
dc.subjectprotective effecten_US
dc.subjectratsen_US
dc.titleThe Protective Effect of Ebselen on Radiocontrast-Induced Nephrotoxicityen_US
dc.typeArticleen_US

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