The osteoinductive potential of different root-end filling materials in a rat femur model

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dc.contributor.authorAksu, Seckin
dc.contributor.authorDelikan, Ebru
dc.contributor.authorKucuk, Ayse Ozcan
dc.contributor.authorAsoglu, Zehra Demiray
dc.contributor.authorYilmaz, Sakir Necat
dc.date.accessioned2024-09-18T21:05:05Z
dc.date.available2024-09-18T21:05:05Z
dc.date.issued2024
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractIn pediatric dentistry, the enduring success of root-end filling materials employed for the establishment of apical plugs in immature teeth undergoing endodontic intervention is contingent upon their possessing a robust osteoinductive capacity. Hence, the primary objective of this study was to histologically assess the osteoinductive potential of four distinct dental materials, specifically recommended for retrograde filling applications, utilizing an animal hard tissue model. Within the designed experimental model, two bone defects measuring 2 mm in diameter and 2 mm in depth were created in both femurs of a cohort comprising 21 male Wistar albino rats. The first defect in the right femur was left blank as the control group, and Neo MTA Plus was placed in the second defect. The EndoSequence BCRRM Fast Set Putty was placed in the first of the defects on the left femur, and Endo Repair was placed in the second defect. Subjects were sacrificed after 7, 14, and 28 days of follow-up, and sections were examined to assess the degree of inflammation, connective tissue formation, and new bone formation. The data were statistically evaluated with Kruskal-Wallis and post hoc Dunn's tests using SPSS 12 software. The bone healing levels of the Neo MTA Plus group were significantly higher than those of the other groups in all periods (p < 0.05). Bone organization in all groups decreased over time, and fibrous tissue was enriched. The results of this study demonstrate that NeoMta Plus has superior osteoinductive properties compared to other materials but that EndoSequence and Endo Repair have the potential to be developed.en_US
dc.description.sponsorshipMersin University Scientific Research Projects Commission [2018-2-AP4-2915]en_US
dc.description.sponsorshipThis study was supported by the Mersin University Scientific Research Projects Commission with project number 2018-2-AP4-2915. It was presented as an oral presentation on 07.10.2022 at the 28th International Turkish Society of Pediatric Dentistry Congress, Antalya, Turkey. We thank Ms. Ebru Osmano & gbreve;lu Akyol, for her technical support for the statistical analysis in this paper.en_US
dc.identifier.doi10.1038/s41598-024-52584-5
dc.identifier.issn2045-2322
dc.identifier.issue1en_US
dc.identifier.pmid38267563en_US
dc.identifier.scopus2-s2.0-85183003872en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1038/s41598-024-52584-5
dc.identifier.urihttps://hdl.handle.net/20.500.12483/13341
dc.identifier.volume14en_US
dc.identifier.wosWOS:001150811100029en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherNature Portfolioen_US
dc.relation.ispartofScientific Reportsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMineral Trioxide Aggregateen_US
dc.subjectImmature Dog Teethen_US
dc.subjectNeo Mta Plusen_US
dc.subjectRepair Materialen_US
dc.subjectConnective-Tissueen_US
dc.subjectProroot Mtaen_US
dc.subjectBiocompatibilityen_US
dc.subjectBiodentineen_US
dc.subjectCementen_US
dc.subjectPasteen_US
dc.titleThe osteoinductive potential of different root-end filling materials in a rat femur modelen_US
dc.typeArticleen_US

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