Effects of erdosteine on hemostasis: An experimental study

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dc.contributor.authorTutanc, M.
dc.contributor.authorArica, V.
dc.contributor.authorMotor, S.
dc.contributor.authorBasarslan, F.
dc.contributor.authorErden, E. S.
dc.contributor.authorOzturk, O. H.
dc.contributor.authorZararsiz, I.
dc.date.accessioned2024-09-18T20:19:49Z
dc.date.available2024-09-18T20:19:49Z
dc.date.issued2012
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractAim: In this study, the effects of erdosteine (ED) on the platelet function and coagulation were investigated in adult rats. Materials and Method: Twenty-eight male Wistar albino rats were divided into four groups. The control rats in group I (n = 7) were given only 0.5 cc of normal saline daily through oral gavage. Group II (n = 7) rats were administered 3 mg/kg ED through oral gavage for 3 days; while group III (n = 7) rats were given 10 mg/kg ED through oral gavage for 3 days; and group IV (n = 7) rats were administered 30 mg/kg ED through oral gavage for 3 days. Prothrombin time (PT), activated prothromboplastin time (aPTT), international normalized ratio (INR), coagulation factors and complete blood counts were measured from the blood drawn. Results: There were a lot of differences between ED groups and control group, and among ED groups. The found differences were level of PT, aPTT, INR, coagulation factors, and number of platelets. Discussion: We consider that ED which is used as a mucolytic agent in child clinics may affect hemostasis and coagulation in a dose-dependent manner. ED should be used carefully by the patients with coagulation disorders, since there is no information available in the package insert and literature screening regarding the effect of ED.en_US
dc.identifier.doi10.1177/0960327111426588
dc.identifier.endpage578en_US
dc.identifier.issn0960-3271
dc.identifier.issn1477-0903
dc.identifier.issue6en_US
dc.identifier.pmid22045892en_US
dc.identifier.scopus2-s2.0-84861795415en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage574en_US
dc.identifier.urihttps://doi.org/10.1177/0960327111426588
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9878
dc.identifier.volume31en_US
dc.identifier.wosWOS:000304222400006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofHuman & Experimental Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecterdosteineen_US
dc.subjecthemostasisen_US
dc.subjectcoagulationen_US
dc.titleEffects of erdosteine on hemostasis: An experimental studyen_US
dc.typeArticleen_US

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