Endometrial Injury Upregulates Expression of Receptivity Genes in Women with Implantation Failure

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dc.authorscopusid7004349870
dc.authorscopusid57218649492
dc.authorscopusid56331646100
dc.authorscopusid57193709296
dc.authorscopusid10439050500
dc.authorscopusid56369756800
dc.authorscopusid57219858233
dc.contributor.authorCelik, Onder
dc.contributor.authorYurci, Arzu
dc.contributor.authorErsahin, Aynur
dc.contributor.authorGungor, Nur D.
dc.contributor.authorCelik, Nilufer
dc.contributor.authorOzcil, Mustafa D.
dc.contributor.authorDogan, Serdar
dc.date.accessioned2024-09-19T15:47:09Z
dc.date.available2024-09-19T15:47:09Z
dc.date.issued2023
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground: Homeobox genes A10 (HOXA10) and A11 (HOXA11), members of the abdominal B gene family, are responsible for embryonic survival and implantation. This study was planned to investigate whether endometrial injury alters the expression of both transcripts in women with implantation failure. Methods: A total of 54 women with implantation failure were divided into two equal groups as experimental (scratching) and sham (no scratching). Participants in the scratching group were exposed to endometrial injury in the mid-luteal phase, and those in the sham group were exposed to endometrial flushing. The scratching group, but not the sham group, underwent prior endometrial sampling. A second endometrial sampling was performed on the scratching group in the mid-luteal phase of the following cycle. The mRNA and protein levels of the HOXA10 and 11 transcripts were determined in endometrial samples collected before and after injury/flushing. Participants in each group underwent IVF/ET in the cycle after the second endometrial sampling. Results: Endometrial injury caused a 60.1-fold (p < 0.01) increase in HOXA10 mRNA and a 9.0-fold increase in HOXA11 mRNA (p < 0.02). Injury resulted in a significant increase in both HOXA10 (p < 0.001) and HOXA11 protein expression (p < 0.003). There was no significant change in HOXA10 and 11 mRNA expressions after flushing. Clinical pregnancy, live birth, and miscarriage rates of the both groups were similar. Conclusions: Endometrial injury increases homeobox transcript expression at both mRNA and protein levels. © 2023 by the authors.en_US
dc.identifier.doi10.3390/ijerph20053942
dc.identifier.issn1661-7827
dc.identifier.issue5en_US
dc.identifier.pmid36900953en_US
dc.identifier.scopus2-s2.0-85149742208en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.3390/ijerph20053942
dc.identifier.urihttps://hdl.handle.net/20.500.12483/15012
dc.identifier.volume20en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation.ispartofInternational Journal of Environmental Research and Public Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectendometriumen_US
dc.subjectfertility outcomeen_US
dc.subjecthomeobox geneen_US
dc.subjectimplantation failureen_US
dc.subjectmRNAen_US
dc.subjectproteinen_US
dc.titleEndometrial Injury Upregulates Expression of Receptivity Genes in Women with Implantation Failureen_US
dc.typeArticleen_US

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