Retinal teratogenicity of pregabalin in chick embryo model

Basit Öğe Kaydı
dc.authoridSecinti, Ilke Evrim/0000-0002-8614-3971
dc.contributor.authorSecinti, Ilke Evrim
dc.date.accessioned2024-09-18T20:08:14Z
dc.date.available2024-09-18T20:08:14Z
dc.date.issued2020
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground Pregabalin is a gamma-aminobutyric acid analog that binds to the alpha 2-delta subunits of the pre-synaptic voltage-dependent calcium channels of nerves with a high affinity and selectivity. In this study, the retinal teratogenic potential of pregabalin was investigated in a chick embryo model. Materials and methods Fertilised chicken eggs were divided into groups for administration with different doses of pregabalin. All eggs were opened on the 10th day of incubation. The embryos were dissected and the effects of pregabalin on the retina were investigated histopathologically, morphometrically, and immunohistochemically (Caspase-3). Results There was no statistically significant difference between the low dose pregabalin, control, or vehicle control groups in terms of the number of retina layers and retinal thickness. Medium and high dose pregabalin caused a statistically significant decrease in the number of retina layers, as well as sensory retinal and pigment epithelium layer thicknesses. The outer nuclear and outer plexiform layer did not form in the group administered a medium dose. Similarly, the outer nuclear, outer plexiform, inner nuclear, and inner plexiform layer did not form in the high-dose group. No statistically significant difference was observed between the groups in terms of cellular damage and Caspase-3 expression. Conclusion The use of pregabalin during pregnancy compromises retinal development in a dose-dependent manner. The use of pregabalin in pregnancy causes the aforementioned defects in this system and it may have developmental effects that needs to be further evaluated.en_US
dc.identifier.doi10.1080/15569527.2020.1802739
dc.identifier.endpage310en_US
dc.identifier.issn1556-9527
dc.identifier.issn1556-9535
dc.identifier.issue4en_US
dc.identifier.pmid32722992en_US
dc.identifier.scopus2-s2.0-85089444369en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage304en_US
dc.identifier.urihttps://doi.org/10.1080/15569527.2020.1802739
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8728
dc.identifier.volume39en_US
dc.identifier.wosWOS:000558504200001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofCutaneous and Ocular Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChick embryoen_US
dc.subjectpregabalinen_US
dc.subjectpregnancyen_US
dc.subjectretinaen_US
dc.subjectCaspase-3en_US
dc.subjectdevelopmenten_US
dc.subjectteratogenicityen_US
dc.titleRetinal teratogenicity of pregabalin in chick embryo modelen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ N/A ]
İsim:
Tam Metin / Full Text
Boyut:
1.24 MB
Biçim:
Adobe Portable Document Format
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu