The impact of different antiepileptic drugs on the sedation of children during magnetic resonance imaging

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dc.contributor.authorDavarci, Isil
dc.contributor.authorKarcioglu, Murat
dc.contributor.authorTuzcu, Kasim
dc.contributor.authorBasarslan, Fatmagul
dc.contributor.authorDavran, Ramazan
dc.contributor.authorYengil, Erhan
dc.contributor.authorYilmaz, Cahide
dc.date.accessioned2024-09-18T20:19:48Z
dc.date.available2024-09-18T20:19:48Z
dc.date.issued2014
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground and objectives: The induction and inhibition of cytochrome P450 isoenzymes by antiepileptic drugs lead to changes in the clearance of anesthetic drugs eliminated via hepatic metabolism. We investigated the duration of the sedation and additional anesthetic needs during magnetic resonance imaging in epileptic children receiving antiepileptic drugs that cause either enzyme induction or inhibition. Methods: In American Society of Anesthesiology I-II, 120 children aged 3-10 years were included. Group 1: children using antiepileptic drugs that cause cytochrome P450 enzyme induction; Group 2: those using antiepileptic drugs that cause inhibition; and Group 3: those that did not use antiepileptic drugs. Sedation was induced with the use of 0.05 mg kg(-1) midazolam and 1 mg kg(-1) propofol. An additional 0.05 mg kg(-1) of midazolam and rescue propofol (0.5 mg kg(-1)) were administered and repeated to maintain sedation. The duration of sedation and the additional sedation needed were compared. Results: The duration of the initial dose was significantly shorter in Group I compared with groups II and III (p = 0.001, p = 0.003, respectively). It was significantly longer in Group II compared with groups I and III (p = 0.001, p = 0.029, respectively). The additional midazolam needed for adequate sedation was increased in Group I when compared with groups II and III (p = 0.010, p = 0.001, respectively). In addition, the rescue propofol dose was significantly higher only in Group I when compared with Group III (p = 0.002). Conclusion: In epileptic children, the response variability to the initial sedative agents during the magnetic resonance imaging procedure resulting from the inhibition or induction of the cytochrome P450 isoenzymes by the antiepileptic drugs mandated the titration of anesthetic agents. Copyright (C) 2013 Sociedade Brasileira de Anestesiologia. Publicado por Elsevier Editora Ltda. All rights reserved.en_US
dc.identifier.doi10.1016/j.bjane.2013.10.013
dc.identifier.endpage325en_US
dc.identifier.issn0034-7094
dc.identifier.issn1806-907X
dc.identifier.issue5en_US
dc.identifier.pmid25168436en_US
dc.identifier.scopus2-s2.0-84905528705en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage320en_US
dc.identifier.urihttps://doi.org/10.1016/j.bjane.2013.10.013
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9858
dc.identifier.volume64en_US
dc.identifier.wosWOS:000342772400004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofRevista Brasileira De Anestesiologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEpilepsyen_US
dc.subjectPediatricen_US
dc.subjectAntiepilepticsen_US
dc.subjectSedationen_US
dc.subjectMRIen_US
dc.titleThe impact of different antiepileptic drugs on the sedation of children during magnetic resonance imagingen_US
dc.typeArticleen_US

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