Bisphenol AF Caused Reproductive Toxicity in Rats and Cineole Co-Treatment Exhibited Protective Effect

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dc.authoridUyar, Ahmet/0000-0003-4345-6756
dc.authoridEtyemez, Muhammed/0000-0003-0497-1878
dc.authoridKUZU, Muslum/0000-0002-1375-7673
dc.contributor.authorUyar, Ahmet
dc.contributor.authorCellat, Mustafa
dc.contributor.authorKanat, Ozgur
dc.contributor.authorEtyemez, Muhammed
dc.contributor.authorKutlu, Tuncer
dc.contributor.authorDeveci, Mehmet Zeki Yilmaz
dc.contributor.authorYavas, Ilker
dc.date.accessioned2024-09-18T20:16:51Z
dc.date.available2024-09-18T20:16:51Z
dc.date.issued2024
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBisphenol AF (BPAF) is increasingly used and now found in products intended for human consumption. The protective effect of 1,8-cineole (CIN) against BPAF-induced reproductive toxicity was investigated. Four groups were created, with each group consisting of eight rats: control, BPAF (200 mg/kg), CIN (200 mg/kg), and BPAF + CIN groups. The results demonstrated that the BPAF group exhibited a decline in testosterone levels and a decrease in sperm parameters compared with the control. Additionally, higher levels of MDA were observed, along with lower levels of GSH and GPx activity. CAT activity also decreased slightly. Tnf-alpha, Nf-kappa B levels were significantly higher, and caspase-3 expression was elevated, while PCNA expression decreased. BPAF significantly increased tissue degeneration compared with the control. However, the BPAF + CIN group showed statistically significant improvements in sperm parameters, except for concentration. They also exhibited an increase in testosterone levels and an improvement in MDA and GSH levels compared with the BPAF group. However, GPx activity partially enhanced. Tnf-alpha and Nf-kappa B levels were significantly reduced, and caspase-3 levels declined while PCNA and Bcl-2 levels increased. The Johnsen Testicular Biopsy score showed a substantial increase. Overall, these results suggest that CIN co-treatment in rats enhanced reproductive health and exhibited antioxidant, antiapoptotic, and anti-inflammatory properties against BPAF-induced testicular damage.en_US
dc.description.sponsorshipMustafa Kemal niversitesien_US
dc.description.sponsorshipNo Statement Availableen_US
dc.identifier.doi10.1007/s43032-024-01677-7
dc.identifier.issn1933-7191
dc.identifier.issn1933-7205
dc.identifier.pmid39160422en_US
dc.identifier.scopus2-s2.0-85201540453en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1007/s43032-024-01677-7
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9779
dc.identifier.wosWOS:001293504500001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofReproductive Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEndocrine disruptoren_US
dc.subjectOxidative stressen_US
dc.subjectInfertilityen_US
dc.subjectNatural antioxidanten_US
dc.subjectHerbal medicineen_US
dc.titleBisphenol AF Caused Reproductive Toxicity in Rats and Cineole Co-Treatment Exhibited Protective Effecten_US
dc.typeArticleen_US

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