Direct and indirect effects of kisspeptin on liver oxidant and antioxidant systems in young male rats

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dc.authoridYilmaz, Bayram/0000-0002-2674-6535
dc.authoridOktar, Suleyman/0000-0003-0151-5981
dc.contributor.authorAydin, M.
dc.contributor.authorOktar, S.
dc.contributor.authorYonden, Z.
dc.contributor.authorOzturk, O. H.
dc.contributor.authorYilmaz, B.
dc.date.accessioned2024-09-18T20:28:18Z
dc.date.available2024-09-18T20:28:18Z
dc.date.issued2010
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractKisspeptin is a recently discovered hypothalamic peptide which plays an important role in the central control of reproductive functions We have investigated direct and indirect effects of kisspeptin on the liver oxidative stress in young male rats Twenty-four rats were divided into four groups (n = 6/group) First group served as control and received saline. Kisspeptin-10 was administered to the animals in the second group (20 nmol/rat/day), for a period of 7 days Rats were given only one dose gosereline (0 9 mg/rat), a GnRH agonist in the third group The last group received kisspeptin-10 with gosereline. The activities of catalase, superoxide dismutase (SOD), xanthine oxidase (XO), adenosine deaminase (AD) and level of malondialdehyde were studied in liver tissue Serum samples were separated for total antioxidant capacity (TAC), total oxidant status (TOS), alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase, blood urea nitrogen (BUN), colesterol, lipoprotein (HDL) and triglyceride. Kisspeptin increased the activities of SOD and catalase (p < 0 05) When compared to the control group. the levels of malondialdehyde. TOS and AST were lower, but levels of BUN, cholesterole, HDL and AD were higher in the other three groups (p < 0.05) In conclusion, our findings suggest that kisspeptin may have antioxidant and thus protective effects on the liver tissue Copyright (C) 2010 John Wiley & Sons, Ltden_US
dc.identifier.doi10.1002/cbf.1656
dc.identifier.endpage299en_US
dc.identifier.issn0263-6484
dc.identifier.issn1099-0844
dc.identifier.issue4en_US
dc.identifier.pmid20517893en_US
dc.identifier.scopus2-s2.0-77953526784en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage293en_US
dc.identifier.urihttps://doi.org/10.1002/cbf.1656
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10833
dc.identifier.volume28en_US
dc.identifier.wosWOS:000279581800007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofCell Biochemistry and Functionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectkisspeptinen_US
dc.subjectreactive oxygen species (ROS)en_US
dc.subjectcatalaseen_US
dc.subjectsuperoxide dismutase (SOD)en_US
dc.subjecttotal antioxidant capacity (TAC)en_US
dc.subjecttotal oxidant status (TOS)en_US
dc.subjectgoserelineen_US
dc.titleDirect and indirect effects of kisspeptin on liver oxidant and antioxidant systems in young male ratsen_US
dc.typeArticleen_US

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