Evaluation of atherosclerotic risk factors and carotid intima media thickness in healthy offspring of type 2 diabetic patients

Basit Öğe Kaydı
dc.authorscopusid16231562400
dc.authorscopusid36865459100
dc.authorscopusid26631843700
dc.authorscopusid23977758900
dc.authorscopusid35574329600
dc.authorscopusid8453910800
dc.authorscopusid24170616100
dc.contributor.authorUstun, I.
dc.contributor.authorAydin, Y.
dc.contributor.authorArduç, A. Ar?
dc.contributor.authorBerker, D.
dc.contributor.authorOzuguz, U.
dc.contributor.authorY?lmaz, M.
dc.contributor.authorErden, G.
dc.date.accessioned2024-09-19T15:43:40Z
dc.date.available2024-09-19T15:43:40Z
dc.date.issued2010
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractAim is to evaluate atherosclerotic risk factors and carotid intima media thickness [CIMT] in offspring of type 2 Diabetes Mellitus [DM] patients with normal glucose tolerance. Methods. We evaluated 96 offspring of Type 2 DM patients and 39 healthy control who were in similar age, sex and body mass. We measured fasting blood glucose [FBG], postprandial blood glucose [PBG], insulin, uric acid, homocystein, fibrinogen, HOMA-IR, lipid profile, hsCRP, microalbuminuria, glycosylated hemoglobin A1c and CIMT by Doppler ultrasonography. Results. FBG was found higher in study group [p<0.001]. The HOMA-IR was 1.7±0.98 and 1.2±0.58 mg/dL x uUI/mL for study and control group, respectively [p=0.007]. TCholesterol, triglycerides, HDL-C, LDL-C and homocystein levels were not different. HsCRP and fibrinogen levels were higher in study group [p=0.014 and p=0.035, respectively]. Microalbuminuria levels were higher in study group but not significant [p=0.111]. CIMT in study group increased distinctively [p<0,001]. In regression analysis, being in study group causes a significant increase on the mean CIMT level by 0.057 mm [0.029-0.086] Conclusion. Our study demonstrated that various atherosclerotic risk factors are aggregated in offspring of Type 2 DM patients having NGT even before they develop glucose intolerance. Having a diabetic family alone might be effective in developing increased CIMT.en_US
dc.identifier.doi10.4183/aeb.2010.227
dc.identifier.endpage227en_US
dc.identifier.issn1841-0987
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-79960459578en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage211en_US
dc.identifier.urihttps://doi.org/10.4183/aeb.2010.227
dc.identifier.urihttps://hdl.handle.net/20.500.12483/14494
dc.identifier.volume6en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofActa Endocrinologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAtherosclerosisen_US
dc.subjectCarotid intima media thicknessen_US
dc.subjectDiabetes mellitusen_US
dc.subjectOffspringen_US
dc.titleEvaluation of atherosclerotic risk factors and carotid intima media thickness in healthy offspring of type 2 diabetic patientsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu