Biomedical effects of Laurus nobilis L. leaf extract on vital organs in streptozotocin-induced diabetic rats: Experimental research

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dc.authoridYENER, Zabit/0000-0002-6365-5843
dc.authoridOmer, Abdullah/0000-0001-8514-3657
dc.authoridUyar, Ahmet/0000-0003-4345-6756
dc.authoridRafaat, Rebin/0000-0002-7622-8218
dc.contributor.authorMohammed, Rebin Rafaat
dc.contributor.authorOmer, Abdullah Khalid
dc.contributor.authorYener, Zabit
dc.contributor.authorUyar, Ahmet
dc.contributor.authorAhmed, Avin Kawa
dc.date.accessioned2024-09-18T20:15:08Z
dc.date.available2024-09-18T20:15:08Z
dc.date.issued2021
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractDiabetes mellitus (DM) has been treated with herbs for centuries and many herbs reported to exert antidiabetic activity. Laurus nobilis is an aromatic herb belonging to the Lauraceae family, commonly known as bay. This study aimed to investigate the activity of Laurus nobilis leave extracts on histopathological and biochemical changes in beta-cells of streptozotocin (STZ)-induced diabetic rats. Thirty healthy adult male albino rats were included in the study and divided equally into 5 groups for 4 weeks as follow; control group (C), diabetic group (D), diabetic Laurus nobilis extract group (DLN), Laurus nobilis extract group (LN) and diabetic acarbose (DA) group. Histopathologically, D group rats exhibited various degenerative and necrotic changes in their liver, pancreas and kidney, whereas the DLN rats had nearly normal histology. Insulin immunostaining in the pancreatic beta cells was decreased in the D group compared to the C group, whereas the DLN group was similar to the C group. The glucose concentration decreased significantly in both diabetic rats treated with L. nobilis and acarbose (p < 0.05). Additionally, the levels of aspartate aminotransferase (AST), gamma-glutamyltransferase (GGT) and alanine aminotransferase (ALT) enzyme were significantly decreased in both diabetic rats treated with L. nobilis and acarbose, compared to the D group (p (>) 0.05). Outcomes of this study said that leave extracts of L. nobilis has valuable effect on blood glucose level and ameliorative effect on regeneration of pancreatic islets, it also restored the altered liver enzymes, urea, creatine kinase, total protein levels, calcium and ferritin to near normal.en_US
dc.description.sponsorshipVan Yuz.ncu Yil University [2015-SBE-YL309]en_US
dc.description.sponsorshipThe authors wish to acknowledge Van Yuz.ncu Yil University for the support (Grant number 2015-SBE-YL309).en_US
dc.identifier.doi10.1016/j.amsu.2020.11.051
dc.identifier.endpage197en_US
dc.identifier.issn2049-0801
dc.identifier.pmid33520200en_US
dc.identifier.scopus2-s2.0-85097473461en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage188en_US
dc.identifier.urihttps://doi.org/10.1016/j.amsu.2020.11.051
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9474
dc.identifier.volume61en_US
dc.identifier.wosWOS:000610075800004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofAnnals of Medicine and Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDiabetes mellitusen_US
dc.subjectLaurus nobilisen_US
dc.subjectStreptozotocinen_US
dc.subjectHistopathologyen_US
dc.subjectBlood glucoseen_US
dc.titleBiomedical effects of Laurus nobilis L. leaf extract on vital organs in streptozotocin-induced diabetic rats: Experimental researchen_US
dc.typeArticleen_US

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