The amoebicidal activity of three substances derived from benzothiazole on Acanthamoeba castellanii cysts and trophozoites and its cytotoxic potentials

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dc.authoridYUCEL, HASAN/0000-0001-9157-1594
dc.contributor.authorOzpinar, Necati
dc.contributor.authorCulha, Gulnaz
dc.contributor.authorKaya, Tugba
dc.contributor.authorYucel, Hasan
dc.date.accessioned2024-09-18T19:48:01Z
dc.date.available2024-09-18T19:48:01Z
dc.date.issued2021
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractAcanthamoeba species are free-living amoebae isolated from many ecological areas such as swimming pools, dams, lakes, soil, and air filters. These amoebae are usually causing granulomatous amebic encephalitis and amebic keratitis in immunosuppressive individuals. In this study, the reproductive potential and morphological changes determined of Acanthamoeba castellanii trophozoite and cyst forms exposed to three different active substances derived from benzothiazole. Furthermore, the cytotoxic potential of these active substances determined by XTT analysis. In the study, axenic cultures prepared for Acanthamoeba castellanii cyst and trophozoite forms and parasite exposed to different concentrations of active substances. Cell counts of parasite cultures were performed at the 30 minutes, 1st, 6th, 12th, 24th, and 48th hour periods. As a result of the study, the reproductive potential suppressive effects of all three substances on Acanthamoeba castellanii trophozoites and cysts were determined. The most effective of these substances was 2-Amino-6(trifluoromethoxy)-benzothiazole. In the first three concentrations of this substance (0.1%, 0.05%, 0.025%), no determined trophozoite and cysts at the end of twenty four. Due to its strong ameobicidal effect, it is thought that 2-Amino-6(trifluoromethoxy)-benzothiazole may be a new therapeutic agent in diseases caused by acanthamoeba parasites by supporting this study with animal experiments.en_US
dc.description.sponsorshipHatay Mustafa Kemal University Scientific Research Projects Coordination Unit [19.M.048]en_US
dc.description.sponsorshipThis study was supported by Hatay Mustafa Kemal University Scientific Research Projects Coordination Unit (Project number: 19.M.048)en_US
dc.identifier.doi10.1016/j.actatropica.2021.105981
dc.identifier.issn0001-706X
dc.identifier.issn1873-6254
dc.identifier.pmid34048787en_US
dc.identifier.scopus2-s2.0-85107425390en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.actatropica.2021.105981
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7295
dc.identifier.volume220en_US
dc.identifier.wosWOS:000670319300003en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofActa Tropicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcanthamoeba castellanii cytotoxic effecten_US
dc.subjectAmeobicidial effecten_US
dc.subject2-Amino-6(trifluoromethoxy)-benzothiazoleen_US
dc.subject13-Benzothiazole-6-sulfonyl chlorideen_US
dc.subjectRiluzole (2-Amino-6-(trifluoromethoxy)en_US
dc.subjectbenzothiazole)en_US
dc.titleThe amoebicidal activity of three substances derived from benzothiazole on Acanthamoeba castellanii cysts and trophozoites and its cytotoxic potentialsen_US
dc.typeArticleen_US

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