Simultaneous Determination of Dopamine and Uric Acid in the Presence of Ascorbic Acid at the Indole-3-Carboxaldehyde Modified Glassy Carbon Electrode

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dc.contributor.authorDeletioglu, Didem
dc.contributor.authorHasdemir, Erdogan
dc.contributor.authorSolak, Ali O.
dc.date.accessioned2024-09-18T20:32:55Z
dc.date.available2024-09-18T20:32:55Z
dc.date.issued2010
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractIndole-3-carboxaldehyde (In3C) molecules were deposited on the glassy carbon (GC) electrode by electrochemical methods in acetonitrile (containing 0.05 M TBATFB). Deposition of In3C was performed by cyclic voltammetry scanning from 0.0 V to 2.0 V at a scan rate of 50 mV s(-1) for 10 cycles in 1 mM In3C solution. The modified surface (In3C-GC) was characterized by cyclic voltammetric response of ferrocene as a redox probe. Elemental composition of the surface was analyzed by X-ray photoelectron spectroscopy (XPS). The applicability of this modified surface was then investigated for the determination of dopamine (DA) and uric acid (UA) in the presence of ascorbic acid (AA) using differential pulse voltammetry. Detection limits were calculated as 1.70 mu M for DA and 4.99 mu M for UA. The linear ranges of the calibration curves were found between 10 mu M -100 mu M for both DA and UA in the presence of 100 mu M AA. The proposed method was applied to the determination of DA and UA in pharmaceutical preparations and urine samples with satisfactory results.en_US
dc.description.sponsorshipTUBITAK (Scientific and Technological Research Council of Turkey) [106T622]en_US
dc.description.sponsorshipThis work was supported by TUBITAK (Scientific and Technological Research Council of Turkey) project with a number of 106T622. The authors thank Dr. Selda Keskin, from Middle East Technical University (Ankara), for acquiring the XPS spectra.en_US
dc.identifier.doi10.2174/157341110791517025
dc.identifier.endpage208en_US
dc.identifier.issn1573-4110
dc.identifier.issn1875-6727
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-77954675022en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage203en_US
dc.identifier.urihttps://doi.org/10.2174/157341110791517025
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11210
dc.identifier.volume6en_US
dc.identifier.wosWOS:000280525200003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherBentham Science Publ Ltden_US
dc.relation.ispartofCurrent Analytical Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectModified glassy carbonen_US
dc.subjectIndole-3-carboxaldehyde filmen_US
dc.subjectDopamineen_US
dc.subjectAscorbic aciden_US
dc.subjectUric aciden_US
dc.subjectSimultaneous determinationen_US
dc.titleSimultaneous Determination of Dopamine and Uric Acid in the Presence of Ascorbic Acid at the Indole-3-Carboxaldehyde Modified Glassy Carbon Electrodeen_US
dc.typeArticleen_US

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